Our new AJHG paper is online. We develop a new TWAS tool that uses local-ancestry information to improve power of gene mapping in admixed samples. Lead author Taylor Head (now at MD Anderson) did a phenomenal job spearheading this work!
Michael Epstein
🚨New method!
📄CADET: Enhanced transcriptome-wide association analyses in admixed samples using eQTL summary data
🧑🤝🧑 @epsteinstatgen.bsky.social @yjingj.bsky.social & co
CADET is a transcriptome-wide association test for admixed cohorts that leverages
local ancestry information to improve detection of trait-influencing genes. CADET
outperformed existing methods using ...