Csaba Pal Lab's interest includes antibiotic resistance research, systems biology, and microbial experimental evolution. Account run by lab members.
Szeged, Hungary
http://group.szbk.u-szeged.hu/sysbiol/pal-csaba-lab-index.html
Csaba Pal Laboratory
Loading...
#mevoSky
Target type is critical: antibiotics that disrupt membrane integrity while blocking a second essential pathway show markedly reduced resistance evolution in #GramNegative pathogens. #AMR
See the original study in
@natcomms.nature.com
: nature.com/articles/s41....
For more context, see the original thread here: bsky.app/profile/csab...
Elvin’s research at the Biological Research Centre (Szeged, Hungary) tackles a central challenge in medicine: how to design effective drugs that #pathogenic bacteria struggle to resist. The key result: #DualTargeting alone is not sufficient.
Excited to share our collaborative work led by the Szilvia Juhasz and Mate Manczinger @matemanc.bsky.social labs: #cancer mutations converge into five protein-level “fingerprints” that shape tumor immune visibility. Mutation burden alone fails to predict #immunotherapy response! @molsystbiol.org
🎓 Warm congrats to Elvin Maharramov
@m-elvin.bsky.social on a successful PhD defense on the principles of designing #antibiotics with limited #resistance. A timely and elegant contribution to the field of #DrugDevelopment on how to design less resistance-prone antibiotics. More info below👇
Can #gene-loss fuel future #adaptation? Check out this exciting new study from @balazs-papp-lab.bsky.social showing that #compensatory-evolution can generate unexpected metabolic gains. Delighted to have contributed! Congratulations to everyone involved! 👏
C > U mutations generate immunogenic peptides in SARS-CoV-2
APOBEC enzymes—key players of the innate immune system—induce mutations that become fixed in viral genomes and enhance immune recognition.
nature.com/articles/s41...
#COVID_19 #Immunology #virus #infectiousdiseases #vaccine #Genetics
C > U mutations generate immunogenic peptides in SARS-CoV-2 @natcomms.nature.com @matemanc.bsky.social
@csabapallab.bsky.social
www.nature.com/articles/s41...
A dual-target antibiotic strategy, combining membrane disruption with another cellular pathway, shows promise in reducing bacterial resistance, offering a new direction in combating antimicrobial resistance. doi.org/g855sh
Csaba Pal Laboratory
Csaba Pal Laboratory
Csaba Pal Laboratory
Csaba Pal Laboratory
Csaba Pal Laboratory
Csaba Pal Laboratory
Csaba Pal Laboratory
Máté Manczinger
Can harmful gene loss become an evolutionary opportunity?
In our new work in @molbioevol.bsky.social , lab-evolved E. coli lines recovering from metabolic gene loss did more than return to normal: some surpassed wild type on nutrients never seen during lab evolution.
📎 doi.org/10.1093/molb...
