We are interested in evolution and systems biology, including the evolution of metabolism, antibiotic resistance and compensatory evolution.
http://group.szbk.u-szeged.hu/sysbiol/papp-balazs-lab-index.html
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In sum: evolutionary recovery from gene loss can rapidly generate metabolic pre-adaptations without direct selection in those future environments.
We tested 18 compensated lines on 10 alternative carbon sources. Nearly half of the lines showed at least one collateral growth gain. In several cases, the original knockout did not grow, meaning compensation generated latent functional gains—not just repair.
The broader implication: evolutionary novelty can arise through detours. Gene loss followed by growth recovery may not simply repair damage, but reshape the genotype–phenotype map and reveal hidden routes toward new cellular functions.
#ExperimentalEvolution #YeastGenetics #EvolutionaryBiology
These mating gains appear to emerge as by-products of compensatory evolution, involving functional modules such as signaling and polarized morphogenesis. In some evolved lines, enhanced pheromone response suggests rewiring of existing regulatory circuits.
