Excited to share our collaborative work led by the Szilvia Juhasz and Mate Manczinger @matemanc.bsky.social labs: #cancer mutations converge into five protein-level “fingerprints” that shape tumor immune visibility. Mutation burden alone fails to predict #immunotherapy response! @molsystbiol.org
Csaba Pal Laboratory
Our new paper is out:
Five dominant amino acid substitution signatures shape tumour immunity
link.springer.com/article/10.1...
Thread 🧵⬇
#cancer #tumor #immunity #immunotherapy #oncology
Although numerous mutational processes operate in cancer, their functional impacts are unclear. We hypothesised that certain mutation sources preferentially generate amino acid substitutions that evad...
