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Happy and grateful to have contributed to this work. Excited to share a new publication from the Sebastian Group at APC Microbiome Ireland. Many thanks to @tsbschm.bsky.social for the guidance and continued support. Congratulations to all co-authors
πŸš€ Excited to be part of this study! πŸ§ͺ Our research shows that a milk-derived peptide✨ can boost intestinal mucus function even with low fiber intake πŸŒΎβ¬‡οΈ β€” opening the door to a potential new prebiotic 🌱 for supporting gut health πŸ’ͺ🩺.
Our latest work is now online! Explored how obesogenic diets, obesity, and key experimental factors (mouse vendor, sex, microbiota) influence intestinal antimicrobial peptide (AMP) expression
2mo
10mo
10mo
There is a lot of undescribed prokaryotic diversity in existing whole-genome metagenomic data! www.nature.com/articles/s41...
We just released a @biorxivpreprint.bsky.social describing the *microntology*, a lightweight controlled vocabulary that we have been using for a while to tag metagenomes with contextual data. Study by @fullam.bsky.social @vishnuprasoodanan.bsky.social et al: 1/ www.biorxiv.org/content/10.6...
2mo
Vishnu Prasoodanan, PhD
5mo
Vishnu Prasoodanan, PhD
Vishnu Prasoodanan, PhD
A clearer way to describe microbial habitats helps researchers compare #microbiome data. A new paper in #𝐁𝐒𝐨𝐒𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐒𝐜𝐬 introduces microntology: 148 terms and curated annotations for 305,626 #metagenomic samples. @tsbschm.bsky.social @embl.org @vishnuprasoodanan.bsky.social πŸ“° buff.ly/FD1SYYJ
Our study describing `microntology` and annotations for >300k metagenomes is now online in Bioinformatics @academic.oup.com : academic.oup.com/bioinformati... Congratulations to @fullam.bsky.social @vishnuprasoodanan.bsky.social & @biocs.bsky.social ! See the thread below for more details.
We've updated our recent @biorxivpreprint.bsky.social on 'Hidden but discoverable diversity in the global microbiome', led by @vishnuprasoodanan.bsky.social & @omaistrenko.bsky.social www.biorxiv.org/content/10.1...
Most microbial diversity is still missing from genome catalogues. A new paper in @natmicrobiol.nature.com analysed 92,187 metagenomes and found that most discoverable bacterial and archaeal lineages sit in unbinned contigs. πŸ“° buff.ly/Q5XREM7 #Microbiome #Metagenomics @vishnuprasoodanan.bsky.social
Summary. We introduce microntology v1.0, a pragmatic controlled vocabulary of 148 terms to describe microbial habitats and lifestyles, and provide manually curated microntology annotations for >300k m...
www.biorxiv.org
microntology: a lightweight, data-driven controlled vocabulary to describe Earth's microbial habitats
9d
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Oleksandr Maistrenko
Re-analysis of over 92,000 metagenomes reveals hundreds of thousands of previously undescribed Bacterial and Archaeal clades hidden in plain sight.
www.nature.com
Unbinned contigs expand known diversity in the global microbiome - Nature Microbiology
Cataloguing Earth's biodiversity remains one of the most formidable challenges in biology, and the greatest diversity is expected to reside among the smallest organisms: microbes. Yet the ongoing cens...
www.biorxiv.org
Hidden but discoverable diversity in the global microbiome
Sebastian Schmidt
Sebastian Schmidt
Sebastian Schmidt
AbstractMotivation. Data-enabled studies of microbial ecology and evolution depend on high-quality descriptions of microbial habitats, based on curated and
academic.oup.com
microntology: a lightweight, data-driven controlled vocabulary to describe Earth’s microbial habitats
APC Microbiome Ireland
APC Microbiome Ireland
I will write more after the Easter break, but for now congratulations to @vishnuprasoodanan.bsky.social @omaistrenko.bsky.social and all other co-authors (including @fullam.bsky.social @pangenomics.bsky.social @luispedrocoelho.bsky.social @anja1.bsky.social )!
Our study on disentangling the impact of #obesity, #diet, host factors, and #microbiota on small intestinal #antimicrobialpeptide expression is now published in Gut Microbes! Fantastic work by Fabiola PuΓ©rtolas-Balint et al! #microbiomesky #microsky #GastroSky www.tandfonline.com/doi/full/10....
Summer strike #2: Our collaboration work with Arla Foods Ingredients has just been published in Food Research International: www.sciencedirect.com/science/arti... #microsky #gastrosky #microbiomesky #guthealth
2mo
10mo
We just released a @biorxivpreprint.bsky.social describing the *microntology*, a lightweight controlled vocabulary that we have been using for a while to tag metagenomes with contextual data. Study by @fullam.bsky.social @vishnuprasoodanan.bsky.social et al: 1/ www.biorxiv.org/content/10.6...
10mo
5mo
The small intestinal mucosa has the delicate task of allowing absorption of nutrients and limiting microbial colonization at the mucosal surface through production of antimicrobial peptides and pro...
Disentangling the impact of obesity, diet, host factors, and microbiota on small intestinal antimicrobial peptide expression
www.tandfonline.com
Sebastian Schmidt
The colonic mucus layer is the primary interface between the host and the gut microbiota. It serves both as an ecological niche for bacteria and a bar…
www.sciencedirect.com
Milk-derived casein glycomacropeptide improves colonic mucus function under Western-style diet feeding in a sialylation-dependent manner
Summary. We introduce microntology v1.0, a pragmatic controlled vocabulary of 148 terms to describe microbial habitats and lifestyles, and provide manually curated microntology annotations for >300k m...
www.biorxiv.org
microntology: a lightweight, data-driven controlled vocabulary to describe Earth's microbial habitats
Sebastian Schmidt
Bjo:rn Schro:der
Bjo:rn Schro:der