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Today in Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. www.nature.com/articles/s41... More at: x.com/erturklab/st...
Nature research paper: A deep-learning framework reveals whole-body perturbations at cell level go.nature.com/3Pjox61
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An analysis of diet-induced obesity using MouseMapper—a suite of foundation-model-based deep-learning algorithms—identifies structural alterations of the infraorbital branch of the trigeminal ganglia.
go.nature.com
A deep-learning framework reveals whole-body perturbations at cell level - Nature
I was not very much involved in this project from our lab, but I can honestly say that I find this story really amazing!
Super happy to see our work published in @nature.com last week 🤩 By combining whole-body tissue clearing, light-sheet microscopy and AI, we mapped obesity-associated remodeling across the entire mouse body in 3D at cellular resolution. www.nature.com/articles/s41... @erturklab.bsky.social
A deep-learning framework reveals whole-body perturbations at cell level @nature.com @erturklab.bsky.social @dorie00.bsky.social www.nature.com/articles/s41...
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AI Atlas Reveals Hidden Whole-Body-Damage Caused by Obesity Researchers around Prof. Ali Ertürk, #HelmholtzMunich, developed #MouseMapper – an #AI framework that maps disease-related changes throughout the entire mouse body at cellular resolution. 👉 t1p.de/svfv0 @erturklab.bsky.social
Our recent work in @Nature, MouseMapper uses foundation-model AI, mapping perturbations in mouse body cell-by-cell, revealed unexpected facial nerve damage. Proud to see >75K accesses & >60 news stories in the first week. Paper->> www.nature.com/articles/s41... Next www.biorxiv.org/content/10.6...
Ohhh, wow!
Ali Maximilian Erturk
MouseMapper An imaging-omics workflow of whole-mouse analysis Up to single-cell resolution!👹 vDISCO WildDISCO whole-mouse optical clearing #SpatialProteomics Trigeminal ganglia VR annotation of major organs, peripheral nerve & Mφ @erturklab.bsky.social Nature 2026 www.nature.com/articles/s41...
#M1 Launches First Funding Period & Advances Translation in Munich🚀 Seven projects receive €7.45 million through the M1 – Munich Medicine Alliance. #HelmholtzMunich is involved in four funded projects. 👉 t1p.de/disle @tum.de @lmu.de @boyanbonev.bsky.social @erturklab.bsky.social #MunichMedicine
Nature
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Ali Maximilian Erturk
Our recent work in @Nature, MouseMapper uses foundation-model AI, mapping perturbations in mouse body cell-by-cell, revealed unexpected facial nerve damage. Proud to see >75K accesses & >60 news stories in the first week. Paper->> www.nature.com/articles/s41... Next www.biorxiv.org/content/10.6...
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Doris Kaltenecker
Waggoner Lab
Helmholtz Munich
Helmholtz Munich
Markus Elsner
Markus Elsner
🧠 Does brain aging always mean vessel loss? We found the opposite in some aged brains: maladaptive hypervascularization, linked to cognitive decline and blood-brain barrier damage. Check it out below! www.biorxiv.org/content/10.6...
Ali Maximilian Erturk
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Hao Yin
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Ali Maximilian Erturk