Prof @ucsf/immunox, co-founder Solvingfor.org, Immunologist,Immunotherapy pioneer,believer in the power of curiosity,striving to make sense of complicated things, typically enthusiastic.
Max Krummel
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Kuhn, @maxkrummel.bsky.social et al. demonstrate how local gene editing of cancer-associated fibroblasts alters their cell state and, subsequently, the cellular tumor microenvironment rupress.org/jem/article/...
#TME #CAFs #TumorImmunology
In @jem.org, Kuhn, @maxkrummel.bsky.social et al. demonstrate how local gene editing of cancer-associated fibroblasts alters their cell state and, subsequently, the cellular tumor microenvironment rupress.org/jem/article/...
#TME #CAFs #TumorImmunology
If dendritic cells are part of your science,
#DC2026 should be part of your year!
🌍Global DC community in San Diego
✳️New biology & discoveries
Abstracts & registration are OPEN
www.dc2026sandiego.com
⭐️ Come for the science. Stay for the community. @maxkrummel.bsky.social @zunigalab.bsky.social 🔁
Registration is now open and an all-in roster of immunologists anchor the premiere Dendritic cell meeting. www.dc2026sandiego.com/invited-spea... Sunny (blue state) San Diego. Sessions devoted to honoring 15 year anniversary of Nobel prize (Steinman) and translational advances…what is not to like.?
How will our increasingly deep understanding of diverse immune archetypes in cancers guide our search for cures?
This perspective describes a future in which we discover drugs based on transitions of tissue/immunobiology through intermediate states, to health. authors.elsevier.com/a/1llig5TA51...
Intravital imaging of pulmonary lymphatics in #inflammation and metastatic cancer. A new imaging approach developed by Simon Cleary (@simoncleary.bsky.social), Longhui Qiu, Mark Looney and colleagues: https://buff.ly/41msQjZ
@maxkrummel.bsky.social
Tired of traditional peer review?
Join the Discovery Stack Pilot study to help reshape scientific publishing!
Contribute as a Reviewer or an Author.
Learn more here: bit.ly/DiscoverySta...
#ScienceRevolution #PeerImprovement #DiscoveryStackPilot #immunosky
Many tx studies (Mujal... Azizi…)failed to validate M1/M2 signatures in vivo. Many also suspected that calling cells bearing ‘prototypical M2’ genes ‘‘immunosuppressive’ was simplistic + incorrect. Nonetheless many (us too!) leaned on the simplification. Arja addresses the reality head on…thnx JEM
Are so-called 'M2-like' CD206+ macrophages immunosuppressive? On the contrary, we find that they are critical for T cell mediated anti-tumor immunity. Arja Ray drove this study with help from Ken Hu, Kelly Kersten, Alexis Combes and others
www.biorxiv.org/content/10.1...
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
Rather than immune suppression, CD206+ TAMs recruit a tumor-reactive network of CD8 T cells, cDC1s, and NK cells
doi.org/10.1084/jem....
@maxkrummel.bsky.social @jexpmed.bsky.social
