NPP and Member in the News: Repeated teen cannabis use may disrupt dopamine-related brain development, MRI data suggest bit.ly/4xlugcI Check out the original @npp-journal.bsky.social article at bit.ly/4dY3saO
ACNP
In this study, turning off one 🧠 pathway reduced drug seeking—but turning off another made it worse, illustrating “inhibitory” optogenetics can have opposite effects depending on the circuit, revealing new insights into relapse vulnerability
Neuropsychopharmacology
New paper in @npp-journal.bsky.social with @lisannej.bsky.social highlighting prospective predictors for (relatively early) #NSSI onset vary by sex. More to come with this R01 as more #ABCD data become available (including clues for improved prevention and treatment).
www.nature.com/articles/s41...
What beats summer sunshine? 🌞
Reading top-notch science while soaking up rays 😎
See below for the latest from NPP #ThisWeekInNPP
#TWiNPP
#TWiNPP
Rapid computational markers of decision-making predicted daily smoking and cessation outcomes. Higher craving and depressive symptoms forecast more smoking; first-week data alone predicted treatment success
www.nature.com/articles/s41...
#TWiNPP
In a rat model, offspring of dams given uncontrolled gestational oxycodone showed more drug taking and seeking than offspring of self-administering dams, despite similar exposure. Effects were strongest in females
www.nature.com/articles/s41...
Neuropsychopharmacology
#TWiNPP
Adolescent cannabis use tracked with lower subcortical tissue iron in dopamine-rich regions (VTA, pallidum, thalamus), an MRI proxy for dopamine neurophysiology. Concentrates showed stronger links than flower
www.nature.com/articles/s41...
#TWiNPP
Heavy drinkers showed elevated brain acetate oxidation, which dropped after ~1 week of abstinence but normalized to light-drinker levels by 1 month. Alcohol-related shifts in acetate metabolism appear reversible
www.nature.com/articles/s41...
#TWiNPP
Knockdown of enkephalin in the dorsal raphe nucleus raised pain sensitivity and odor aversion while lowering sucrose preference and social interaction—identifying a non-serotonergic population that promotes reward
www.nature.com/articles/s41...
Neuropsychopharmacology
Dr. Mindy Westlund Schreiner
Neuropsychopharmacology
Neuropsychopharmacology
Neuropsychopharmacology
Neuropsychopharmacology
Neuropsychopharmacology - Rapid and reliable computational markers of decision-making for predicting daily smoking behavior and smoking cessation treatment outcomes
Neuropsychopharmacology - Contrasting roles of secondary motor cortex projections to the dorsolateral and dorsomedial striatum in incubation of cocaine-seeking
Neuropsychopharmacology - White matter and impulsivity are prospectively associated with non‑suicidal self‑injury in youth: evidence for sex differences
