Neuropsychopharmacology (NPP) is an official peer-reviewed publication of the American College of Neuropsychopharmacology.
We report discoveries and promote training & outreach initiatives.
Neuropsychopharmacology
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In this study, turning off one 🧠 pathway reduced drug seeking—but turning off another made it worse, illustrating “inhibitory” optogenetics can have opposite effects depending on the circuit, revealing new insights into relapse vulnerability
Neuropsychopharmacology - Contrasting roles of secondary motor cortex projections to the dorsolateral and dorsomedial striatum in incubation of cocaine-seeking
New paper in @npp-journal.bsky.social with @lisannej.bsky.social highlighting prospective predictors for (relatively early) #NSSI onset vary by sex. More to come with this R01 as more #ABCD data become available (including clues for improved prevention and treatment).
www.nature.com/articles/s41...
Neuropsychopharmacology - White matter and impulsivity are prospectively associated with non‑suicidal self‑injury in youth: evidence for sex differences
What beats summer sunshine? 🌞
Reading top-notch science while soaking up rays 😎
See below for the latest from NPP #ThisWeekInNPP
#TWiNPP
#TWiNPP
Adolescent cannabis use tracked with lower subcortical tissue iron in dopamine-rich regions (VTA, pallidum, thalamus), an MRI proxy for dopamine neurophysiology. Concentrates showed stronger links than flower
www.nature.com/articles/s41...
#TWiNPP
Knockdown of enkephalin in the dorsal raphe nucleus raised pain sensitivity and odor aversion while lowering sucrose preference and social interaction—identifying a non-serotonergic population that promotes reward
www.nature.com/articles/s41...
#TWiNPP
In a rat model, offspring of dams given uncontrolled gestational oxycodone showed more drug taking and seeking than offspring of self-administering dams, despite similar exposure. Effects were strongest in females
www.nature.com/articles/s41...
#TWiNPP
Rapid computational markers of decision-making predicted daily smoking and cessation outcomes. Higher craving and depressive symptoms forecast more smoking; first-week data alone predicted treatment success
www.nature.com/articles/s41...
#TWiNPP
Heavy drinkers showed elevated brain acetate oxidation, which dropped after ~1 week of abstinence but normalized to light-drinker levels by 1 month. Alcohol-related shifts in acetate metabolism appear reversible
www.nature.com/articles/s41...
NPP and Member in the News: Repeated teen cannabis use may disrupt dopamine-related brain development, MRI data suggest bit.ly/4xlugcI Check out the original @npp-journal.bsky.social article at bit.ly/4dY3saO
Dr. Mindy Westlund Schreiner
Neuropsychopharmacology
Neuropsychopharmacology
Neuropsychopharmacology - The role of subcortical brain tissue iron as an indicator of dopamine neurophysiology in adolescent cannabis use
Neuropsychopharmacology - Rapid and reliable computational markers of decision-making for predicting daily smoking behavior and smoking cessation treatment outcomes
www.nature.com
Neuropsychopharmacology - Reversible alterations of brain acetate metabolism associated with alcohol consumption
