Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...
Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...
New research from EMBL Rome shows how paternal environment prior to conception can shape early embryo development.
These findings are a step toward understanding the mechanism of epigenetic inheritance, opening up new possibilities for disease prevention.
www.embl.org/news/science...
Jan Ε»ylicz
π£ New preprint from the lab - Endogenous fluctuations of transcription factor levels shape their occupancy in unexpected ways
www.biorxiv.org/content/10.1...
Jamie Hackett
The control of transcription factor (TF) concentrations is crucial for the precise regulation of gene expression and cell fate decisions during development. Yet, TF concentrations can display substant...
