Developmental (epi)genomics group at EMBL Rome
Non-genetic inheritance. Epigenetic editing. ERC investigator 🇮🇹🇬🇧🇮🇪
Jamie Hackett
New research from EMBL Rome shows how paternal environment prior to conception can shape early embryo development.
These findings are a step toward understanding the mechanism of epigenetic inheritance, opening up new possibilities for disease prevention.
www.embl.org/news/science...
A fabulous project led by Alessandro Barenghi & @embl.org Rome facilities (GEVF) @neilhumph.bsky.social+ Jim Sawitzke 👏👏 together with our lab.
📣 New preprint from the lab - Endogenous fluctuations of transcription factor levels shape their occupancy in unexpected ways
www.biorxiv.org/content/10.1...
Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...
🤩🤩 it’s been a while
Awhh, my lab are absolute legends!
Huge shoutout fantastic co-first leads @mdura.bsky.social @bbbranjan.bsky.social and all authors. Great collaboration with the fabulous Ana Boskovic
Project enabled by @embl.org Human Ecosystems transversal theme! 🙏
This went under the radar but answers a fundamental question in Epigenetics...
From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How?
Outstanding work from Mathieu Boulard and colleagues
www.biorxiv.org/content/10.6...
Novel compact CRISPR systems unlock easier delivery and more applications... epigenome editing anyone 👀
Very happy to be involved in work to rationally engineer enhanced Cme2 - an ultra-high fidelity & compact Cas, delivered in vivo in a single AAV (with gRNA)
www.biorxiv.org/content/10.6...
❓Can a father’s environmental exposures before conception influence their offspring?
We systematically tackled this - identifying effects of paternal age, environment and genetics on early embryos - as well as confounding influences
www.embopress.org/doi/full/10....
