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We're a research lab at Rockefeller University (NY) and Necker Hospital (Paris) studying human genetic and immunological determinants of infectious diseases. https://www.hgid.org/

Casanova Lab

THIS IS THE BEST PAPER OF 2026 SO FAR, A MONUMENTAL BREAKTHROUGH, A REVOLUTION IN THE FIELD OF INFLAMMATORY CONDITIONS: Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | New England Journal of Medicine www.nejm.org/doi/10.1056/...

Casanova Lab

HERE IS WHY: Autoantibodies against Cytokines — From Infection to Inflammation | New England Journal of Medicine www.nejm.org/doi/10.1056/...

Ribosomal RNA processing impairments in a B cell immunodeficient patient with WDR75 variants. New study from Nidia Moreno-Corona, Sven Kracker @institutimagine.bsky.social and colleagues: rupress.org/jhi/article/... #RareDisease #ClinicalPhenotypes #InbornErrorsOfImmunity

Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis. From Adrian Gervais, Aurélie Cobat, @casanovalab.bsky.social, Emmanuelle Jouanguy et al: rupress.org/jem/article/... 📘 From our Clinical #Immunology Collection 👉 rupress.org/jem/collecti... #FOCIS2026

Adult-onset STING-associated vasculopathy. New study from Thomas R. Riley, Jonathan J. Kotzin, Amanda V. Finck, Jonathan J. Miner and colleagues (UPenn Perelman School of Medicine): rupress.org/jhi/article/... #Autoimmunity #ClinicalPhenotypes #ImmunologicalPhenotypes #InbornErrorsOfImmunity

FAS-controlled #Tcells drive #lymphoproliferation through #glycolysis without effector differentiation. New study from Maria Elena Maccari, Ramon I. Klein Geltink @bcchresearch.bsky.social, Anne Rensing-Ehl @uni-freiburg.de and colleagues: rupress.org/jhi/article/... #InbornErrorsOfImmunity

Functional characterization of Griscelli syndrome type 2 sine albinism in Japanese patients. New study from Tatsuhiko Tanaka, Akira Sugawara, Ko Kudo (Hirosaki University), Mitsunori Fukuda (Tohoku University) and colleagues: rupress.org/jhi/article/... #InbornErrorsOfImmunity

Primary atopic disorders: Monogenic insights into immunity. Bhavi Modi, Stuart Turvey @turveylab.bsky.social et al. review how primary atopic disorders, a group of monogenic #InbornErrorsOfImmunity, reveal fundamental mechanisms regulating allergic #inflammation. rupress.org/jhi/article/... #Atopy

Using EBV-activated effector T cells as a benchmark, Maccari, Geltink, Rensing-Ehl et al. show that FAS-controlled #Tcells display comparably heightened glycolysis, but a metabolic program uncoupled from T-BET expression and IFNγ production. rupress.org/jhi/article/... #InbornErrorsofImmunity

📢 #FOCIS2026 attendees: Join our Executive Editor Natalie Cain (@nataliecain.bsky.social) TODAY for a "Meet the Editor" session at 11:45 am - 1:00 pm! 💡 Gain insights into the peer review process, and learn how to prepare a manuscript for publication and respond to reviewers’ comments!

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Casanova Lab

Journal of Human Immunity

Journal of Experimental Medicine

Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic defects of interleukin-10 signaling in children and may be associated with inflammatory bowel disease (IBD)...

www.nejm.org

Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | NEJM

The authors describe the scientific foundations of a study implicating autoantibodies against interleukin-10 in persons with inflammatory bowel disease.

www.nejm.org

Autoantibodies against Cytokines — From Infection to Inflammation | NEJM