New research shows bacteria can redefine stop codons by shortening tRNA anticodon stems. This "extended superwobble" proves tRNAs aren't passive—they're active drivers that can evolve entirely new genetic codes! doi.org/10.1093/nar/...
Faculty of Science, University of South Bohemia
A threonine-to-aspartate ACA codon reassignment in uncultivated Acidimicrobiales bacteria https://www.biorxiv.org/content/10.64898/2026.05.03.722492v1
bioRxivpreprint
On DRT3: a fascinating discovery that makes us rethink textbook diagrams, but does it really break the central dogma of molecular biology?
#RNA #PhD #Science
rnastuff.com/2026/05/04/d...
Check out my new post!
It is a short and accessible digest of our recently published work in Nucleic Acids Research, highlighting the main findings and the broader implications of the study.
#RNA #RNAsky #evolution #science #PhD
rnastuff.com/2026/04/20/t...
We have a new preprint on a rare sense-to-sense genetic code reassignment in uncultivated Acidimicrobiales bacteria.
We report evidence that ACA, normally a threonine codon, is reassigned to aspartate in a RAAP-2 lineage.
#tRNA #PhD #evolution
Link: www.biorxiv.org/content/10.6...
Fadel Fakih
Fadel Fakih
Do experiments in model organisms reveal universal biological rules, or only local regularities shaped by evolutionary history?
Here is a short synthesis, inspired by our work, on how comparative genomics helps us distinguish between the two.
#PhD #Biology #RNA
rnastuff.com/2026/05/10/c...
This reassignment first emerged from our broader bacterial genetic code analysis in our recent Fakih et al. NAR 2026 (doi.org/10.1093/nar/...) and here we provide a detailed characterization of its phylogenetic, codon-usage, tRNA, and aminoacylation context.
