In January, the FDA approved a new non-opioid painkiller. CBP's Grégory Scherrer spoke with @theguardian.com about the new wave of developing non-opioid drugs for pain relief. Read here: www.theguardian.com/science/2025...
New from Rothlab!
www.miragenews.com/gene-therapy...
New paper from the lab:
Structure-guided design of a peripherally restricted chemogenetic system
10.1016/j.cell.2024.11.001
www.nature.com/articles/s41...
Nice blurb on our recent paper!
Kang et al. present HCAD, a peripherally restricted DREADD based on HCA2, with a chemical actuator that avoids crossing the blood-brain barrier and selectively reduces pain in mice.
www.cell.com/cell/fulltex...
Cell Biology and Physiology at UNC-CH
UNC Neuroscience Center
I started (at @katesadlerphd.bsky.social's suggestion, thanks Kate for pushing me) a pain neuroscience and pain research starter pack. I am sure I have missed many people so if I missed you, I am sorry, but please just ask me to add you in the thread below and I will do that. go.bsky.app/KboKNhg
Bryan Roth
Bryan Roth
I am glad to share our recent work, now published in Cell! A @zenbrainest.bsky.social and Scherrer lab collaboration developing and validating a new peripherally restricted DREADD system! Great team work with Hye Jin Kang, Brian Krumm, @adrtas.bsky.social, and others
www.cell.com/cell/abstrac...
Bryan Roth
Kang et al. present HCAD, a peripherally restricted DREADD based on HCA2, with a chemical actuator that avoids crossing the blood-brain barrier and selectively reduces pain in mice. This system will enable the study of peripheral physiology without affecting the central nervous system.
