New paper out 🚨! Excited to share this collab between my lab and @kerschensteiner.bsky.social's group, expertly led by Ning Shen. We used a genome-wide in vivo CRISPR screen to uncover novel neuroprotective strategies in the P23H mouse retina, with validation in a new human retina culture model.
Congrats to @ismaelhdeznunez.bsky.social for taking on this project that included 9 different genotypes of TET mutants, and a special thanks to all other co-authors and collaborators.
Excited to share our new manuscript from the Yoshimatsu and MacDonald labs. www.biorxiv.org/content/10.6.... We found that my favourite glial cells can regulate local retinoic acid signalling to specialise cone photoreceptors for high acuity visual function.
We’ve reached a milestone in the lab! Congrats to Dr. Jade Hostetler for a fantastic thesis defense and becoming the first PhD graduate of the Clark lab! Jade has been leading all of our work on RNA biology including studies of Peanut (Gm11454) pubmed.ncbi.nlm.nih.gov/41573818/ and more to come.