We enjoyed putting our heads together with the Jakob and Freddolino labs to find that polyphosphate modulates the formation of functional RNA-protein condensates in response to nitrogen-starvation stress!
journals.plos.org/plosbiology/...
Mapping of DNA-binding sites for 139 E. coli transcription factors
and
A neural network that predicts binding energy from DNA sequence and can be used to design new binding sites
#NeuralNetworks #MachineLearning #Genomics
How do internal promoters within operons shape bacterial stress responses? 🦠🧫
Contributing to a study with @andreribeirolbd.bsky.social, we show non-monotonic spatial expression patterns across operons in E. coli, B. subtilis, C. glutamicum, and H. pylori. www.science.org/doi/10.1126/...
Here come our new palette of fluorescent dyes. The BD dyes endeaves to balance glowy brightness, robust photostability, and biocompatibility. Let's boost 4D dynamic super-resolution imaging!!!
www.nature.com/articles/s41...
@spirochrome.com
We have a tenure-track Assistant Professor position open at Aalto University in the area of Living State Physics with a focus on molecular and cellular biophysics, biophotonics, non-equilibrium phenomena, or biological engineering.
www.aalto.fi/en/open-posi...
Pls share! 🦠🔬🧪🧫
"E. coli nucleoid adopts a condensed, membrane-proximal configuration during rapid growth, an active role of transertion (coupled transcription, translation, and membrane insertion) in nucleoid organization" #microsky www.nature.com/articles/s41...
Our paper on the E. coli Min system in vivo with @physicsoflifelmu.bsky.social & Judy Kim (UCSD) has been published in Nature Physics today. Tight integration of experiment and theory, and physiology and biophysics. Incredible perseverance of our young students. rdcu.be/ekIpO
The authors describe BoltzNet, a neural network that learns the energy of transcription factor (TF)-DNA binding from genomic data and can be used to design new binding sites. They report the in vivo mapping and BoltzNet modeling of 139 E. coli TFs.
Aalto University is where science and art meet technology and business. We shape a sustainable future by making research breakthroughs in and across our disciplines, sparking the game changers of tomorrow and creating novel solutions to major global challenges. Our community is made up of 120 nationalities, 14 000 students, 400 professors and close to 5000 faculty and staff working on our dynamic campus in Espoo, Greater Helsinki, Finland. Diversity is part of who we are, and we actively work to ensure our community’s diversity and inclusiveness. This is why we warmly encourage qualified candidates from all backgrounds to join our community.
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The mechanisms underlying bacterial chromosome configuration are not fully understood. Here, Spahn et al. show that the Escherichia coli nucleoid adopts a condensed, membrane-proximal configuration du...
www.nature.com
Nature Physics - Oscillatory Min protein patterns prevent abnormal bacterial cell division. Now it is shown that Min pattern formation is resource efficient and involves wavelength-invariant...
Internal promoters in operons are critical in genome-wide stress responses, compensating for frequent premature RNAP falloffs.
www.science.org
A suite of bridged rhodamine dyes (BriDyes) offers excellent brightness, solubility, photostability, and tunable cell permeability along with resistance to photoblueing, making them exceptional all-pu...
Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...
How does your favorite species elongate? 🧵 "Phenotypic plasticity in bacterial elongation among closely related species". Happy to see this paper in print @natcomms.nature.com. Nice work by @mariedelaby.bsky.social, Liu Yang et al. See original 🧵, different colours, same data and conclusions.
Nature Communications - Multiple types of cell elongation have been described in bacteria, but little is known about how these strategies vary across species. Here, the authors use fluorescent...
How does your favorite species elongate? 🧵 "Phenotypic plasticity in bacterial elongation among closely related species" by @mariedelaby.bsky.social, Liu Yang et al https://buff.ly/48Kw96x. How do cells elongate, all over, poles, middle? Close species do it the same way right? Not quite! #Microsky
