Nucleotide Metabolism, Molecular Metabolism, and Signaling Pathways
https://www.bensahralab.org/
Ben-Sahra Lab
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Pleased to share our recent work out today in @natmetabolism.nature.com. This study addresses a longstanding mystery - NRF2-driven cancers increase cysteine acquisition (via xCT) by ~5x - so where does all that cysteine go?
RESEARCH | C Hepler, J Bass et al. (Northwestern University) 🧪
Circadian clock in adipocytes maintains metabolic health by regulating mitochondrial complex I respiration.
Hot off the press!! 🚨📰 Check out @palpurab.bsky.social work focusing on the effect of ceramides on breast cancer cells aacrjournals.org/mcr/article/...
RESEARCH | S Xiao, M Wang, TG Martin, J Long et al
@stanfordmedicine.bsky.social
Para-tyramine-O-sulphate is a conserved postprandial metabolite that links nutrient intake to energy balance in pythons and mice🧪
www.nature.com/articles/s42...
Exciting breakthrough technology from the lab, now live in
@cellcellpress.bsky.social
! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!
#Autophagy and #mTOR papers from last week, very interesting stuff going on in the field, don’t miss it! 👇🏼
biomed.news/bims-auttor/...
#Mitochondria in #Health and #Disease - last 2 weeks of published research 📚:
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social
Mito control of glycerolipid synthesis by a PEP shuttle
www.cell.com/cell/abstrac...
Also, check out this excellent N&V writeup from @frezzalab.bsky.social that nicely summarizes our findings and contextualizes them with other fascinating work on succinate interactions with nucleotide synthesis from the @bensahralab.bsky.social and Hirschey Labs!
www.nature.com/articles/s42...
Cell metabolism is a dynamic network of highly interconnected biochemical reactions. In this issue of Nature Metabolism, time-lapse analysis of the amino acid aspartate revealed an unexpected regulati...
www.nature.com
Nature Metabolism
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Metastasis-associated oncofetal cell states emerge at the earliest stages of colorectal cancer and spatial profiling shows stereotypic patterning of fibroblast subtypes resembling normal tissue archit...
Leveraging pythons as an extreme model of feeding and fasting behaviour, this study uncovers para-tyramine-O-sulphate as a conserved postprandial metabolite that links nutrient intake to energy balanc...
Nature Metabolism, Published online: 03 April 2026; doi:10.1038/s42255-026-01491-2This study demonstrates that overexpression of irisin, an exercise-induced myokine, ameliorates obesity and insulin resistance in high-fat-diet-fed mice by increasing local IL-33 production and preserving ST2+ regulatory T cells in white adipose tissues.
Abstract. Despite the success of endocrine therapy (ET) in treating hormone receptor-positive breast cancer, a significant proportion of patients relapse during or after treatment, making ET resistanc...
Nature Metabolism, Published online: 07 April 2026; doi:10.1038/s42255-026-01499-8Previously uncharacterized cysteine-derived conjugates, including with endogenous sugar metabolites, accumulate in cancer cells with constitutive NRF2 activation and account for some of the increased cystine uptake that cannot be explained by conventional cysteine metabolism.
