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and the News & Views www.nature.com/articles/d41...
new out in Nature www.nature.com/articles/s41...
new out in Nature www.nature.com/articles/s41...
New out in Nature, a Perspective some 20 years after the original studies in Nature showing synthetic lethality between BRCA mutations and PARP inhibition www.nature.com/articles/s41...
new out in Nature www.nature.com/articles/s41...
new out in Nature this week www.nature.com/articles/s41...
new out in Nature www.nature.com/articles/s41...
new out in Nature www.nature.com/articles/s41...
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Depletion of sex hormones that enable male development induces neuroinflammation that disrupts hormonal signalling and immune responses against brain tumours.
www.nature.com
Male sex hormone loss aids brain tumour growth
new out in Nature: www.nature.com/articles/s41...
Androgens have distinct roles in the brain, acting as immune-based tumour suppressors through neuroinflammation and neuroendocrine mechanisms.
www.nature.com
Androgen loss accelerates brain tumour growth via HPA axis activation - Nature
l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...
www.nature.com
Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite - Nature
The past two decades of PARP inhibitor synthetic lethality in cancer is explored.
Two decades of PARP inhibitor synthetic lethality in cancer - Nature
www.nature.com
new out in Nature www.nature.com/articles/s41...
Ecotypes of triple-negative breast cancer in response to chemotherapy - Nature
Treatment data for triple-negative breast cancer show the importance of macrophage subtypes and cancer-cell metaprograms for interferon signalling, HLA expression and cell cycle activity that are asso...
www.nature.com
Multimodal machine learning reveals that tumour microenvironments can be decomposed into spatially organized multicellular ecosystems, termed spatial ecotypes, that can be accessed non-invasively via ...
www.nature.com
Non-invasive profiling of the tumour microenvironment with spatial ecotypes - Nature
The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications f...
www.nature.com
αKG-mediated carnitine synthesis drives DNA repair via histone acetylation - Nature
1mo
Barbara Marte
Barbara Marte
Barbara Marte
Barbara Marte
Barbara Marte
Barbara Marte
Barbara Marte
Barbara Marte
1mo
DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...
www.nature.com
Evolutionary characterization of lung cancer metastasis - Nature
A genome-to-genome association study identifies host and viral risk factors that interact to drive nasopharyngeal carcinoma endemicity in southern China.
EBV strain interacts with host HLA to drive nasopharyngeal carcinoma risk - Nature
www.nature.com
Tumour network mapping of diffuse midline glioma (DMG) defines a conserved and prognostically important brain network in children with DMG, consistent with the hypothesis that DMGs exploit otherw...
www.nature.com
A prognostic human brain network for diffuse midline glioma - Nature
Barbara Marte
Barbara Marte