Treatment data for triple-negative breast cancer show the importance of macrophage subtypes and cancer-cell metaprograms for interferon signalling, HLA expression and cell cycle activity that are asso...
www.nature.com
www.nature.com
The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications f...
and the News & Views
www.nature.com/articles/d41...
new out in Nature www.nature.com/articles/s41...
Barbara Marte
Barbara Marte
new out in Nature www.nature.com/articles/s41...
New out in Nature, a Perspective some 20 years after the original studies in Nature showing synthetic lethality between BRCA mutations and PARP inhibition www.nature.com/articles/s41...
new out in Nature www.nature.com/articles/s41...
DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...
new out in Nature this week www.nature.com/articles/s41...
Barbara Marte
Depletion of sex hormones that enable male development induces neuroinflammation that disrupts hormonal signalling and immune responses against brain tumours.
www.nature.com
A genome-to-genome association study identifies host and viral risk factors that interact to drive nasopharyngeal carcinoma endemicity in southern China.
Androgens have distinct roles in the brain, acting as immune-based tumour suppressors through neuroinflammation and neuroendocrine mechanisms.
www.nature.com
Barbara Marte
Barbara Marte
Barbara Marte
l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...
The past two decades of PARP inhibitor synthetic lethality in cancer is explored.
www.nature.com
Multimodal machine learning reveals that tumour microenvironments can be decomposed into spatially organized multicellular ecosystems, termed spatial ecotypes, that can be accessed non-invasively via ...
Tumour network mapping of diffuse midline glioma (DMG) defines a conserved and prognostically important brain network in children with DMG, consistent with the hypothesis that DMGs exploit otherw...
