3D multi-omics tumour atlases: from technology to biology and clinical translation
www.nature.com/articles/s41...
In this Review, Liu et al. describe the established and emerging tools for the generation of comprehensive 3D tumour atlases, the analysis of which has the potential to uncover novel biomarkers for ri...
We GoT a Fillingโฆuuuuhoooo
๐ง๐ฎ๐ฟ๐ด๐ฒ๐๐ฒ๐ฑ ๐๐ฒ๐พ๐๐ฒ๐ป๐ฐ๐ถ๐ป๐ด ๐ผ๐ณ ๐บ๐๐๐ฎ๐๐ถ๐ผ๐ป๐ ๐๐ถ๐ฎ ๐ฅ๐ก๐-๐๐ฒ๐บ๐ฝ๐น๐ฎ๐๐ฒ๐ฑ ๐ด๐ฎ๐ฝ ๐ณ๐ถ๐น๐น๐ถ๐ป๐ด ๐ผ๐ณ ๐ผ๐น๐ถ๐ด๐ผ๐ป๐๐ฐ๐น๐ฒ๐ผ๐๐ถ๐ฑ๐ฒ๐ ๐ณ๐ผ๐ฟ ๐๐ถ๐ป๐ด๐น๐ฒ-๐ฐ๐ฒ๐น๐น ๐ฅ๐ก๐-๐๐ฒ๐พ
www.biorxiv.org/content/10.6...
Luciano Martelotto
www.biorxiv.org
New work from our @mgrillo.bsky.social with @lgmartelotto.bsky.social and others. Capture somatic mutations in single-cell assays via RNA-targeted gap filling. Check it out!
Capturing somatic mutations in single-cell probe-based assays (ie. 10X Flex) is a hard task, especially if you don't know *exactly* the mutations you want to capture, or if your target sequence is a mutational hotspot with many possible alternative alleles. Here's the way we pulled this off. Enjoy!
It's cool to see we aren't the only ones that think rationally designed probes + gapfilling is the future. Check out a corroborating workflow from @mgrillo.bsky.social, @lgmartelotto.bsky.social, Anna Nam, and colleagues: bsky.app/profile/mgri... 7/n
Capturing somatic mutations in single-cell probe-based assays (ie. 10X Flex) is a hard task, especially if you don't know *exactly* the mutations you want to capture, or if your target sequence is a mutational hotspot with many possible alternative alleles. Here's the way we pulled this off. Enjoy!
Mats Nilsson's Lab
We GoT a Fillingโฆuuuuhoooo
๐ง๐ฎ๐ฟ๐ด๐ฒ๐๐ฒ๐ฑ ๐๐ฒ๐พ๐๐ฒ๐ป๐ฐ๐ถ๐ป๐ด ๐ผ๐ณ ๐บ๐๐๐ฎ๐๐ถ๐ผ๐ป๐ ๐๐ถ๐ฎ ๐ฅ๐ก๐-๐๐ฒ๐บ๐ฝ๐น๐ฎ๐๐ฒ๐ฑ ๐ด๐ฎ๐ฝ ๐ณ๐ถ๐น๐น๐ถ๐ป๐ด ๐ผ๐ณ ๐ผ๐น๐ถ๐ด๐ผ๐ป๐๐ฐ๐น๐ฒ๐ผ๐๐ถ๐ฑ๐ฒ๐ ๐ณ๐ผ๐ฟ ๐๐ถ๐ป๐ด๐น๐ฒ-๐ฐ๐ฒ๐น๐น ๐ฅ๐ก๐-๐๐ฒ๐พ
www.biorxiv.org/content/10.6...
2026 HCA Asia Meeting in the land of Oz! ๐ซถ๐ซถ๐ซถ
events.humancellatlas.org/2026asia/Home
Capturing somatic mutations in single-cell probe-based assays (ie. 10X Flex) is a hard task, especially if you don't know *exactly* the mutations you want to capture, or if your target sequence is a mutational hotspot with many possible alternative alleles. Here's the way we pulled this off. Enjoy!
www.science.org/doi/10.1126/...
Why so serious? ๐
Marco Grillo, Anna Nam and yours truly ๐๐ผ๐ง ๐ฎ ๐๐ถ๐น๐น๐ถ๐ป๐ด that will make you happy ๐
No more limitations. Maximum flexibility.
Something is coming. Stay tuned.
#singlecellwithaplus
We GoT a Fillingโฆuuuuhoooo
๐ง๐ฎ๐ฟ๐ด๐ฒ๐๐ฒ๐ฑ ๐๐ฒ๐พ๐๐ฒ๐ป๐ฐ๐ถ๐ป๐ด ๐ผ๐ณ ๐บ๐๐๐ฎ๐๐ถ๐ผ๐ป๐ ๐๐ถ๐ฎ ๐ฅ๐ก๐-๐๐ฒ๐บ๐ฝ๐น๐ฎ๐๐ฒ๐ฑ ๐ด๐ฎ๐ฝ ๐ณ๐ถ๐น๐น๐ถ๐ป๐ด ๐ผ๐ณ ๐ผ๐น๐ถ๐ด๐ผ๐ป๐๐ฐ๐น๐ฒ๐ผ๐๐ถ๐ฑ๐ฒ๐ ๐ณ๐ผ๐ฟ ๐๐ถ๐ป๐ด๐น๐ฒ-๐ฐ๐ฒ๐น๐น ๐ฅ๐ก๐-๐๐ฒ๐พ
www.biorxiv.org/content/10.6...
