Murray CH. Clarke @murrayclarkelab.bsky.social & team find common CHIP mutations produce distinct sex-dependent effects on atherosclerosis and differentially affect macrophage cytokines and clonal expansion, arguing against a common mechanism across CHIP: doi.org/10.1172/jci....
New Cambridge BHF-funded 4 year PhD Programme.
Bringing together researchers from Oxford and Cambridge to develop innovative, cross-disciplinary approaches to halt, stabilise and reverse vascular disease.
Please apply here:
www.postgraduate.study.cam.ac.uk/courses/dire...
New Paper Alert! Hard getting this one out... Huge kudos to Paul Carter for immense amounts of experimentation - Common clonal hematopoiesis driver mutations have disparate effects on macrophage cytokines, clonal expansion, and atherogenesis. insight.jci.org/articles/vie...
❤️@thebhf.bsky.social 💰
Last Friday, our Department came together at our Annual Research Day 2025 to share discoveries, spark new ideas, and build the collaborations that will carry us forward.
Discover the highlights ➡️ buff.ly/wDaHWGC
@medcambridge.bsky.social #ResearchDay
@vpd-hlri.bsky.social
Very excited to have helped out on this excellent study where IL-1:IL-1R2 controls Tcell contraction.! 👍
Now I'm contracting back to the safety of innate immunity... 😂
Online now: A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction
New opportunity to join us at the @vpd-hlri.bsky.social in Cambridge, UK as a Lab Manager. More info and link to apply here: www.jobs.cam.ac.uk/job/50050/
Working also with Bennett group, @murrayclarkelab.bsky.social from @cambridgecardio.bsky.social
dlvr.it
The pathways regulating Th1 cell contraction are not well understood. Rahman et al. demonstrate that complement receptor C5aR2 controls T cell-intrinsic prostanoid metabolism as an integral component of Th1 cell contraction. Faulty C5aR2-prostanoid rewiring marks autoimmunity-associated hyper-Th1 cell responses in arthritis and Crohn’s disease. Therefore, prostanoid metabolism is a potentially druggable checkpoint for the cessation of Th1 cell effector responses.
My lab has an opening for a postdoctoral research associate
@unmc-chvr.bsky.social @unmcphysiology.bsky.social @unmccom.bsky.social
Open immediately, for the job description and application, please follow the link: unmc.peopleadmin.com/postings/90764
A Postdoctoral Research Associate position is available in the laboratory of Dr. Mabruka Alfaidi, in the Department of Cellular and Integrative Physiology. The Alfaidi Lab has a long-standing interest...
Thanks @thebhf.bsky.social. @vpd-hlri.bsky.social @medcambridge.bsky.social @cam.ac.uk medcambridge.bsky.social and all the co-authors I can't find on here...
