Very excited to have helped out on this excellent study where IL-1:IL-1R2 controls Tcell contraction.! 👍
Now I'm contracting back to the safety of innate immunity... 😂
Online now: A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction
The pathways regulating Th1 cell contraction are not well understood. Rahman et al. demonstrate that complement receptor C5aR2 controls T cell-intrinsic prostanoid metabolism as an integral component of Th1 cell contraction. Faulty C5aR2-prostanoid rewiring marks autoimmunity-associated hyper-Th1 cell responses in arthritis and Crohn’s disease. Therefore, prostanoid metabolism is a potentially druggable checkpoint for the cessation of Th1 cell effector responses.
