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This was a really fun and interesting Molecule of the Month to do! Check out the article to see even more elaborate RNA-only structures.
That increased versatility of the genetic code through alternate mRNA processing is generally deleterious is why I think we should award a Nobel to Joan Steitz and Lynne Maquat for “the elucidation of the molecular grammar of the genetic code and it’s importance in mRNA quality control.” Overdue.
Matthew D. Giammar et al.: Leopard-EM: an extensible 2D template-matching package to accelerate in situ structural biology #InSituStructuralBiology #CryoEM #CryoET @usc...#IUCr https://journals.iucr.org/paper?S2059798325009982
Join us for a Presidential Lecture on 1/28 with Eva Nogales: "Visualizing Structure, Dynamics and Interactions Using Cryo-EM." Register: https://www.simonsfoundation.org/event/visualizing-structure-dynamics-and-interactions-using-cryo-em/ #science #biology
Muyuan Chen has turned structural biology into an immersive experience with his new video game Meowtabolism, now available on Steam.
Try the demo here: store.steampowered.com/app/4045010/...
Give Muyuan feedback: steamcommunity.com/app/4045010
#ScienceGaming #StructuralBiology #CryoEM #STEMOutreach
@flatironinstitute.org senior research scientist Pilar Cossio builds crucial tools to reveal how environmental changes alter the behavior of RNA: https://bit.ly/48rCAg2 #science #biology
Excited to share our work uncovering SNOR, a ribosome-associated factor that promotes translation restart after dormancy published in Nature!! This was, as usual, a wonderful collaborative effort between our group and the Mattei Lab @simonemattei.bsky.social @embl.org www.nature.com/articles/s41...
MRC Laboratory of Molecular Biology
Congratulations to Matthew and Josh! Check out our extensible Python based 2DTM package, check out our example adaptations for optimizing template parameters and constrained searches and customize to suit your own experiments. Stay tuned for exciting future developments in the pipeline :)
Janet Iwasa
Nominations for the June Almeida award for Mid/Senior-Career Women in Cryo-EM are now open! Submit your nomination via this link www.biophysics.org/awards-fundi... by November 14th to recognize an exceptional woman in our community.
Bronwyn Lucas
Edward T Eng
Structural Biology
Bronwyn Lucas
Simons Foundation
Simons Foundation
Ahmad Jomaa
Bronwyn Lucas
Video
Large and intricate naturally occurring structures composed exclusively of RNA... ROOL!
More at Molecule of the Month: pdb101.rcsb.org/motm...
Flatiron Institute researcher Pilar Cossio builds tools to analyze experimental measurements and reveal how environmental changes alter the behavior of RNA molecules.
In situ cryo-EM coupled with 2D template matching (2DTM) holds the potential to visualize the cellular structureome in context, but further developments are required to make this a reality. We describe Leopard-EM (Location and orientation of particles found using two-dimensional tEmplate Matching), an extensible Python package for 2DTM to accelerate in situ structural biology.
journals.iucr.org
"Some suggested that transcript diversity is adaptive, while others contended that it is largely deleterious and arises from molecular errors in transcription and RNA processing (...).
The data supports the error hypothesis and suggests that metazoan transcript diversity is largely deleterious"
Explore the interior of an algal cell on your four paws. Built with experimental data and populated with actual protein structures, Meowtabolism offers a glimpse of the vast world inside the basic fun...
This single author paper has to be seen to be believed.... My 'GIF' does it no justice
Chen, M. (2023) ‘Rendering protein structures inside cells at the atomic level with Unreal Engine’, bioRxiv.
doi.org/10.1101/2023...
Alternative transcription initiation, splicing and polyadenylation generate extensive transcript diversity in eukaryotes, but its evolutionary significance has been disputed. This study analyses 166 t...
Now out in full form. Again, a big thanks to #teamtomo and @alisterburt.bsky.social for developing the infrastructure to build this on. journals.iucr.org/d/issues/202...
Matthew Collins
In situ cryo-EM coupled with 2D template matching (2DTM) holds the potential to visualize the cellular structureome in context, but further developments are required to make this a reality. We describ...
