That increased versatility of the genetic code through alternate mRNA processing is generally deleterious is why I think we should award a Nobel to Joan Steitz and Lynne Maquat for “the elucidation of the molecular grammar of the genetic code and it’s importance in mRNA quality control.” Overdue.
Bronwyn Lucas
"Some suggested that transcript diversity is adaptive, while others contended that it is largely deleterious and arises from molecular errors in transcription and RNA processing (...).
The data supports the error hypothesis and suggests that metazoan transcript diversity is largely deleterious"
Alternative transcription initiation, splicing and polyadenylation generate extensive transcript diversity in eukaryotes, but its evolutionary significance has been disputed. This study analyses 166 t...
