Out today in @cp-molcell.bsky.social!
We show that proximal polyadenylation site (pPAS) within MRE11 sustains its transcription through promoter–PAS chromatin looping.
Congratulations to first author Kaimeng Huang, all co-authors and collaborators.
www.sciencedirect.com/science/arti...
Alternative polyadenylation (APA) generates transcript isoforms with variable 3′ untranslated regions (UTR) lengths, yet its role in DNA damage respon…
Excited to share that Michelle Swift has been selected as an OCRA grantee! This support will help us study mechanisms of PARP inhibitor resistance in ovarian cancer and identify new therapeutic opportunities. ocrahope.org/research/cur...
We are looking for a candidate with hands-on experience in NGS to drive workflows in fundamental genome stability research and clinical genomics. This role offers the opportunity to work on cutting-edge sequencing projects both within our lab and in collaboration with clinical teams across DFCI.
inally, we demonstrate that PAS‑mediated promoter looping broadly regulates DDR gene expression and genome stability, expanding the conceptual framework for how DDR factors are controlled.
Deletion of the MRE11 pPAS reduces MRN complex abundance and phenocopies hypomorphic MRE11 defects. We further find that loss of the pPAS triggers ectopic DNA replication and confluence‑induced cell death, revealing non‑canonical, non‑DDR functions linked to MRE11.
Thank you for highlighting our work!
Chowdhury Lab
Congratulations to @susankilgas.bsky.social on receiving the first place Best Poster Award at the DNA Damage Mutation and Cancer Gordon Research Conference for her poster on a novel layer of p53 regulation through TIRR 🎉
The Chowdhury Lab at the Dana-Farber Cancer Institute is hiring a Senior Research Technician!
If you are passionate about NGS and its applications in cancer research, apply here: careers.dana-farber.org/job/650/seni...
Congratulations to @chiaramasnovophd.bsky.social on receiving the @americancancersoc.bsky.social Postdoctoral Fellowship! 🎉 Her project will be defining the DNA Repair Independent Mitotic Role of 53BP1
Well deserved recognition of outstanding work!
Big congratulations to @susankilgas.bsky.social, who won a Poster Presentation Award at the 20th International p53 Workshop | p53 Conference, which took place last week in Toronto!
Fantastic work! #p53biology @danafarber.bsky.social
Chowdhury Lab
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1. A new @cp-molcell.bsky.social paper from @chowdhurylab.bsky.social that shows proximal polyadenylation site (pPAS) within MRE11 sustains its transcription through promoter–PAS chromatin looping.
ACS supported this work through Dr. Ke Cong's postdoc fellowship.
doi.org/10.1016/j.mo...
