A lab at the MRC LMB, Cambridge. Interested in dynein, microtubules, cytoskeleton, electron microscopy and much more.
Carter Lab
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In our #journalclub, we looked at the cool new findings from Deng and colleagues, which show that the bacterial reverse transcriptase Drt3 chain B can synthesise poly(AC) DNA strands in the absence of a nucleic acid template, encoded by conserved surface amino acids.
www.science.org/doi/10.1126/...
Thrilled to see this work published. Thanks to helpful reviewer suggestions, there are some exciting new insights that were not in the preprint (particularly in Figure 4).
www.nature.com/articles/s41...
It’s done!! Molecular architecture of the ciliary base in mammalian multiciliated cells! A study 13 years in the making 👴, thanks to collab with @stearnslab.bsky.social + @centriolelab.bsky.social & visionary work by @computingcaitie.bsky.social, who integrated native #cryoET with #XLMS & #UExM 🧪🧶🧬🔬
Carter Lab
Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...
Beautiful new study from @dyneinassembly.bsky.social lab on cilia recycling.
Come and work with us on #cryoEM of alpha-synuclein amyloid filaments from #Parkinsons disease! 🥳
fa-evzn-saasfaukgovprod1.fa.ocs.oraclecloud.com/hcmUI/Candid...
Really proud to see this. Huge congratulations to @helenfoster.bsky.social on the Biochemical Society Early Career Award, well deserved!!
Simon Bullock
Always looking for ways to improve cryo-ET lamella quality. In last week’s #journalclub, we discussed what seems to be a promising and practical in-chamber sublimation approach for mitigating ice contamination and curtaining during lamella prep.
Preprint-- www.biorxiv.org/content/10.6...
New preprint from the lab, looking at how multiple different adaptors interact with dynein! Work led by @amicoennio.bsky.social.
Available now on BioRxiv: doi.org/10.64898/202...
Our story on RNA recognition by Egl-BicD is now published!
Also delighted to share the accompanying News & Views article by Florence Besse and Andres Ramos, which beautifully highlights the work.
Paper: www.nature.com/articles/s41...
News & Views: www.nature.com/articles/s41...
£42,694 per annum | Fixed-term for 3 years | Full-time | Closing date: 17 May 2026
Defense-associated reverse transcriptases (DRTs) are widespread bacterial anti-phage systems that use unconventional mechanisms of polynucleotide synthesis. We show that DRT3, which comprises two dist...
The hidden rules behind mRNA transport.
A collaborative study between @simonbullock11.bsky.social & @carter-lab.bsky.social’s groups has found a structural code that explains how cells selectively transport mRNAs.
Read more: mrclmb.ac.uk/news-events/...
#LMBNews @cellbiol-mrclmb.bsky.social 🧪
I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...
Video
Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...
Happy to share our latest work spearheaded by super talented PhD student Muyang Ren now out as a bioRxiv preprint.
'Motile ciliophagy promotes ciliary recycling under stress'
www.biorxiv.org/content/10.6...
Caitie McCafferty
The hidden rules behind mRNA transport.
A collaborative study between @simonbullock11.bsky.social & @carter-lab.bsky.social’s groups has found a structural code that explains how cells selectively transport mRNAs.
Read more: mrclmb.ac.uk/news-events/...
#LMBNews @cellbiol-mrclmb.bsky.social 🧪
MRC Laboratory of Molecular Biology
I am delighted to be among this years winners awards from the Biochemical Society! The Early Career Award recognises the work I did during my PhD and postdoc, and hopefully signals a bright start for my new lab within the @astbury-bsl.bsky.social at the University of Leeds 💫
(GIRISH)MALI LAB
www.biorxiv.org
Helen Foster
New preprint! We asked a simple question:
How do very different activating adaptors all activate dynein?
Turns out: same architecture, wildly different implementations 🧵👇
doi.org/10.64898/202...
doi.org
Ennio
We are so proud of all our Biochemical Society 2027 Award winners. Visit our website to find out more about all of the deserving recipients #BiochemAwards 🧪
https://ow.ly/mZ6O50YIGo8
