Phages invented sgRNAs before humans!! 🧬
Obviously, for mischief… 😈
Loved seeing this story unfold!
@romihadary.bsky.social and @soreklab.bsky.social 's discovery that sponge proteins constitute enormous families of viral immune evasion factors is now out in @natmicrobiol.nature.com
@reneechang.bsky.social and our lab were happy to help with this story!
www.nature.com/articles/s41...
Our aRES story is finally out 😀
Beyond what was reported in the preprint, we found that aRES is activated by direct binding of the phage DNA polymerase.
Another NAD-degrading defense system — and multiple phage strategies to overcome it.
www.sciencedirect.com/science/arti...
(1/6) Thrilled to share this story! In our preprint from my PhD in the @kranzuschlab.bsky.social, with help from the Hatfull lab and @soreklab.bsky.social, we discover RyDEP, a phage-encoded RyR-domain glycosidase that allows phages to evade Thoeris defense. Highlights below! doi.org/10.64898/202...
1/8 🚨 New preprint from the @sternberglab.bsky.social & @martinjinek.bsky.social labs! CRISPR-associated transposases (CASTs) insert large DNA cargoes at precise genomic locations — no double-strand breaks needed.
Amazing piece from @science.org and @richardastone.bsky.social on our field and the growing connection between human and bacterial immunity!
#microsky #virosky #immunosky
www.science.org/content/arti...
Like a prophage being awakened from its slumber, the phage field has seen a lot of renewed activity during the last decade. Check out our new @natrevmicro.nature.com review on the temperate phage life cycle here to stay up-to-date 🧫🦠
www.nature.com/articles/s41...
Excited to see this online! The structure of the CAST type I holo-complex. Congrats to all involved! By the labs of @martinjinek.bsky.social & @sternberglab.bsky.social.
A better understanding of battles between bacteria and viruses could inspire new medicines
www.science.org
The life cycle of temperate bacteriophages involves lytic or lysogenic cycles and has historically served as a model for studying genetic regulation. This Review provides an updated overview of these ...
Some phages are named after gods or rivers, this one was named by journalist Thilo Mischke @thilomischke.bsky.social after his grandma ("Oma Karin") while filming in our lab.
It's a cool phage that should be temperate but became virulent due to a transposon at its lysogeny control! ⛓️💥💪🏼
Many bacterial defense systems restrict phage infection by breaking down the molecule nicotinamide (Nam) adenine dinucleotide (NAD+) into adenosine di…
