Phages invented sgRNAs before humans!! 🧬
Obviously, for mischief… 😈
Loved seeing this story unfold!
Rafael Pinilla-Redondo (Rafa)
Phage-encoded single-guide RNAs subvert CRISPR-Cas9 immunity https://www.biorxiv.org/content/10.64898/2026.06.01.729453v1