Inlay

Hassan Zafar et al.: Breaking barriers: transitioning from X-ray crystallography to cryo-EM for structural studies #CryoElectronMicroscopyCryoEM #StructuralBiology #SingleParticleAnalysis @uvmvermont...#IUCr https://journals.iucr.org/paper?S205979832600080X

The LSI labs of David H. Sherman and Filipa Pereira have teamed up to boost bacterial production of a long-elusive compound, leading to a potential new treatment for drug-resistant malaria. Read more: research.umich.edu/research-sto...

Applications for the 2026 #CryoET Data Processing Workshop are due one month from today! Learn more about this hands-on workshop and apply by March 20: myumi.ch/lsi-cryo-workshop-2026

In a new "Look to Leadership" column, LSI Director Roger Cone discusses the importance of using programs such as the Aspirnaut Summer Research Internship to provide life-changing opportunities for future scientists. myumi.ch/Nrqrk

Congratulations to LSI faculty member David Ginsburg, who has received the @isth-official.bsky.social 2026 Outstanding Mentor Award in honor of his "ongoing commitment to cultivate and mentor early career professionals in the thrombosis and hemostasis field."

While everything feels flash-frozen in Michigan, it's a great time to plan for U-M's 2026 #CryoET Data Processing Workshop! This hands-on workshop will introduce participants to standard image processing packages used to analyze cryo-ET data. Apply by March 20: myumi.ch/lsi-cryo-wor...

What to viruses have to do with cancer? Microbiologist @drsprggs.bsky.social explains why her lab is probing the pathways that viruses use to get into a host cell's nucleus, and how this research can shed light on the ways viruses either induce or combat cancer: www.youtube.com/watch?v=7f_Q...

The deadline to register for the 2026 Cryo-ET Workshop has been extended extended to April 10! Learn more about this hands-on workshop and apply at: myumi.ch/lsi-cryo-workshop-2026 @jbquerido.bsky.social @shyamalm.bsky.social

Join us this summer for U-M's 2026 #CryoET Data Processing Workshop! This four-day workshop will introduce participants to standard image processing packages and all aspects of cryo-ET data processing. Apply by March 20: myumi.ch/lsi-cryo-workshop-2026 @jbquerido.bsky.social @shyamalm.bsky.social

This article describes the transition of the Glass laboratory from X-ray crystallography to single-particle cryo-electron microscopy (cryo-EM) for structural studies of ATAD2B, a large AAA+ ATPase- and bromodomain-containing protein involved in chromatin regulation. It outlines practical strategies for protein expression, sample preparation, data processing and model building, offering a comprehensive workflow and troubleshooting guide for new cryo-EM users working with large, flexible macromolecular complexes.