Special thanks to my co-authors Talya and @amitaig.bsky.social for contributing to the phage experiments and biochemistry, and to Aaron, @federicalocci.bsky.social, Silvina, and Elke in MPIPZ who helped with plant experiments and made my trips to Cologne both productive and enjoyable.
How do pathogens disarm plant immunity?
We discovered a widespread strategy used by plant bacterial pathogens: they directly cleave a conserved immune signaling molecule produced by plant immune receptors.
www.biorxiv.org/content/10.6...
A detailed thread soon, but first, thanks to all my great colleagues and friends in @soreklab.bsky.social, the Schulze-Lefert lab, and @parkergroup.bsky.social (@mpipz.bsky.social) for their support and many fruitful discussions.
Ohad Roth
www.biorxiv.org
Ohad Roth
Ohad Roth
A nice piece at @science.org covers the exploding field of bacterial immunity, and how it led to the understanding that components of the human immune system evolved from bacterial defenses against phage
www.science.org/content/arti...
Excited to see our work out in @natmicrobiol.nature.com! We uncovered broad functional diversity within phage sponge families🧽.
Huge thanks to all coauthors and brilliant collaborators @kranzuschlab.bsky.social @reneechang.bsky.social !
www.nature.com/articles/s41...
Our aRES story is finally out 😀
Beyond what was reported in the preprint, we found that aRES is activated by direct binding of the phage DNA polymerase.
Another NAD-degrading defense system — and multiple phage strategies to overcome it.
www.sciencedirect.com/science/arti...
🚨After 4 fantastic years in the Sorek lab @soreklab.bsky.social, I’ll be starting my own group at EMBL @embl.org bl.org Hamburg.
www.embl.org/groups/oster...
Metabolism-driven immunity: phages, metabolites, and discovery of new enzymes, molecules, and pathways 🦠🧬
How do human cells defend against viruses?
@sgfern.bsky.social discovers that human immune proteins named ISGs target ancient features of replication shared between animal and bacterial viruses – opening analysis of human immunity to the power of bacterial genetics
www.biorxiv.org/content/10.6...
A better understanding of battles between bacteria and viruses could inspire new medicines
TIRs are key regulators of plant immunity, but the role of conserved TIR-only proteins has remained unclear.
Here, we compare TIR-only proteins from Arabidopsis and barley and show that they share a conserved role in plant immunity.
www.biorxiv.org/content/10.6...
A functional screen reveals phage sponge proteins that bind Pycsar, Thoeris and CBASS signalling molecules to inhibit bacterial immunity.
www.nature.com
Many bacterial defense systems restrict phage infection by breaking down the molecule nicotinamide (Nam) adenine dinucleotide (NAD+) into adenosine di…
