Together with @harnoslab.bsky.social, we compiled what is known about direct interactions of Wnt and Notch components, and advanced the testable framework of how the crosstalk could allow for a more polarized cellular response to one pathway or the other.
Author copies of our new book on statistics (mainly) for life scientists arrived recently. After three years of work, this is exciting, especially as we really hope it can help make a positive difference.
What's so special about it?
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Today at PI_Forum Brno we will discuss this graph.
From 62% women at PhD level to 17% at professor level.
Letās talk about why this happensāand how to change it. š CEITEC MU | š 17:30 czexpats.org/en/udalost/p... @czexpats.bsky.social
Paper alert! š¤ Cells talk to one another all the time using cascades of protein interactions. Now, we know for quite some time that proteins from different cascades can interact with each other. It's called crosstalk. But doesn't it defy the logic of clear communication channels between cells? š§
Thanks for the kind words Alfonso! Very happy to discuss and learn from you if you would be interested.
Excited to share our new study, now out on bioRxiv: www.biorxiv.org/content/10.6...
In this work, we identify CK1Ī± as a novel positive regulator of NOTCH1 signaling and uncover a previously unknown phosphorylation-dependent regulatory mechanism centered on N1ICD residue S1970.
