PI at CUNI Prague🇨🇿, Karolinska Institutet🇸🇪, Czexpat🌍, Junior Faculty chair. Notch & Wnt in development and disease 🔬🧫🐁. *All views my own; 🇪🇺🇺🇦 https://maseklab.org
Jan Mašek
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Special thanks to @fabioturetti.bsky.social, one of my first PhD students, who drove this project with exceptional persistence and creativity, @harnoslab.bsky.social for their passion and scientific insight, and everyone else helping us along the way!
#WNT, #NOTCH, #CellSignaling
Today at PI_Forum Brno we will discuss this graph.
From 62% women at PhD level to 17% at professor level.
Let’s talk about why this happens—and how to change it. 📍 CEITEC MU | 🕠 17:30 czexpats.org/en/udalost/p... @czexpats.bsky.social
Author copies of our new book on statistics (mainly) for life scientists arrived recently. After three years of work, this is exciting, especially as we really hope it can help make a positive difference.
What's so special about it?
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Excited to share our new study, now out on bioRxiv: www.biorxiv.org/content/10.6...
In this work, we identify CK1α as a novel positive regulator of NOTCH1 signaling and uncover a previously unknown phosphorylation-dependent regulatory mechanism centered on N1ICD residue S1970.
Paper alert! 🤓 Cells talk to one another all the time using cascades of protein interactions. Now, we know for quite some time that proteins from different cascades can interact with each other. It's called crosstalk. But doesn't it defy the logic of clear communication channels between cells? 🧐
By combining cell biology, structural modeling, NMR, mass spectrometry, and Xenopus in vivo assays, we show how CK1α activity supports assembly of the active NOTCH1 transcriptional complex.
Go Anna go!
Huge thanks to @fabioturetti.bsky.social, Marek Dokoupil, and the one and only Giovanna Collu, who worked on this review, and to @amartinezarias.bsky.social who pioneered this field pubmed.ncbi.nlm.nih.gov/22326376/ 🫶. #Wnt #Notch pubmed.ncbi.nlm.nih.gov/41558807/ #openbiology
Great article about starting a lab at @sciencecharles.bsky.social and the positive effect of supportive peer community from my colleague and co-chair of JF Vito @geohazards.group. For more context check also my article in @vedavyzkumcz.bsky.social - vedavyzkum.cz/nazory/nazor....
Together with @harnoslab.bsky.social, we compiled what is known about direct interactions of Wnt and Notch components, and advanced the testable framework of how the crosstalk could allow for a more polarized cellular response to one pathway or the other.
