5/ Just like in @elphegenoralab.bsky.social and Leonid's study, the hypothesis that long-lived cohesin-driven encounters mediate E-P communication explains how enhancer effect scales with genomic distance (exponentially) and is decoupled from total contact probabilities measured in Hi-C (power-law)
3/ Cohesin bridges in @elphegenoralab.bsky.social & Leonid Mirny's new study identify with the loop-extrusion-driven long-lived encounters that we recently discovered using polymer simulations and super-high resolution live imaging:
2/ This is very much in line with and extends our recent discovery that loop extrusion creates rare, but long-lived cohesin-mediated encounters that lasting longer than random contacts and provide support for E-P communication:
👉https://www.biorxiv.org/content/10.1101/2025.09.24.678119v1.full
