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new out in Nature this week www.nature.com/articles/s41...
new out in Nature www.nature.com/articles/s41...
new out in Nature www.nature.com/articles/s41...
new out in Nature www.nature.com/articles/s41...
new out in Nature www.nature.com/articles/s41...
New out in Nature, a Perspective some 20 years after the original studies in Nature showing synthetic lethality between BRCA mutations and PARP inhibition www.nature.com/articles/s41...
and the News & Views www.nature.com/articles/d41...
new out in Nature www.nature.com/articles/s41...
new out in Nature: www.nature.com/articles/s41...
new out in Nature www.nature.com/articles/s41...
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Tumour network mapping of diffuse midline glioma (DMG) defines a conserved and prognostically important brain network in children with DMG, consistent with the hypothesis that DMGs exploit otherw...
www.nature.com
The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications f...
www.nature.com
A prognostic human brain network for diffuse midline glioma - Nature
αKG-mediated carnitine synthesis drives DNA repair via histone acetylation - Nature
l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...
www.nature.com
Treatment data for triple-negative breast cancer show the importance of macrophage subtypes and cancer-cell metaprograms for interferon signalling, HLA expression and cell cycle activity that are asso...
www.nature.com
Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite - Nature
Ecotypes of triple-negative breast cancer in response to chemotherapy - Nature
Multimodal machine learning reveals that tumour microenvironments can be decomposed into spatially organized multicellular ecosystems, termed spatial ecotypes, that can be accessed non-invasively via ...
www.nature.com
The past two decades of PARP inhibitor synthetic lethality in cancer is explored.
www.nature.com
Non-invasive profiling of the tumour microenvironment with spatial ecotypes - Nature
Two decades of PARP inhibitor synthetic lethality in cancer - Nature
Male sex hormone loss aids brain tumour growth
Depletion of sex hormones that enable male development induces neuroinflammation that disrupts hormonal signalling and immune responses against brain tumours.
www.nature.com
Androgens have distinct roles in the brain, acting as immune-based tumour suppressors through neuroinflammation and neuroendocrine mechanisms.
www.nature.com
Androgen loss accelerates brain tumour growth via HPA axis activation - Nature
Evolutionary characterization of lung cancer metastasis - Nature
DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...
www.nature.com
A genome-to-genome association study identifies host and viral risk factors that interact to drive nasopharyngeal carcinoma endemicity in southern China.
www.nature.com
EBV strain interacts with host HLA to drive nasopharyngeal carcinoma risk - Nature
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