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Development, evolution, worms, gene name etymology. I log interesting papers, questions, and ideas.
Gavin Woodruff









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Why are leaves the shape that they are? What controls intraspecific, genetic variation in leaf shape? New from my lab, in collaboration with many others, led by PhD student Amanda Peake: mapping the leaf shape polymorphism in Ipomoea hederacea.
How do alternative reproductive modes arise? In this @pnas.org paper, we show that hybridogenesis -where a haploid set of chromosomes is transmitted clonally across generations- acted as an intermediate step between sexual and asexual reproduction in stick insects. doi.org/10.1073/pnas...
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😀 Actually, what is a gain-of-function mutation? doi.org/10.1093/gene...
How predictable is evolution? Replicated C. elegans experiments show environmental differences and population bottlenecks jointly shape the repeatability of adaptation doi.org/10.1093/evle... Image credit: Wikimedia
Comparative transcriptomics reveals an extracellular worm Argonaute as an ancestral regulator of LTR retrotransposons academic.oup.com/gbe/advance-...
Brault et al. propose guidelines for standardized π estimation, systematic reporting of summary statistics, and the adoption of richer metadata to ensure that population genomic data remain comparable and reusable across a wide range of systems. 🔗 doi.org/10.1093/gbe/... #genome #evolution
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Put simply: It coordinates action in more varied and context-dependent ways across more complex environments, AND it regulates a more complex internal environment. Highly recommend this chapter from Sterling and Laughlin! link.springer.com/article/10.1...
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
doi.org
PNAS
The new OrthoFinder paper is out now! In this new work, we introduce major advances in accuracy and scalability, allowing analysis on much larger datasets www.nature.com/articles/s41... github.com/OrthoFinder/...
John Stinchcombe
Luca Soldini
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Gavin Woodruff
Gavin Woodruff
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Evolution Letters
Genome Biology and Evolution
Abstract. For more than a century, scientists have worked to characterize, understand, and predict the consequences of mutations. For almost as long, scien
doi.org
Actually, what is a gain-of-function mutation?
Abstract. Safeguarding the genome from non-self elements is essential for development, reproduction, and ageing. One of the major threats to genomic integr
academic.oup.com
Comparative transcriptomics reveals an extracellular worm Argonaute as an ancestral regulator of LTR retrotransposons
Newly arisen indel governs a leaf shape polymorphism in the Ivy Leaf Morning Glory (Ipomoea hederacea) https://www.biorxiv.org/content/10.64898/2026.06.04.730136v1