Gabilan Assistant Professor of Biological Sciences & Quantitative and Computational Biology @ USC
#GeneRegulation
#NonCodingMechanisms
#TranscriptionFactors
Judith Kribelbauer
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From the article: "So what will happen when everyone decides to ignore the insides, and just trusts the black box? What will happen when people don’t know what questions to ask because they never learned the insides of anything?"
Adding another link. I had a similar experience with a student. The AI output looked so exciting and right that it didn't even occur to them checking whether any of it made sense. spoiler: it didn't tagide.com/blog/llm/the...
Recommend read! Struggling to implement code/bring your thoughts on paper is what builds topic-level expertise. Great tool for everyone already on the other side of the learning journey, but what about trainees? Would I have wanted it for myself when I started out? Not entirely sure.
Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬
Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles
By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪
🧵👇
Excited to share our new study on CpG islands (CGIs) regulation by transcription factors (TFs)! CGIs drive most transcription initiation with unclear regulation. We find that chromatin-opening TFs are key players—following a surprisingly simple rule. 🧵 www.biorxiv.org/content/10.6...
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