We discovered that micronuclei rupture because of proximity to mitochondria! Mitochondria leak Reactive Oxygen Species that alter nuclear export and protein oligomerization. ROS rupture micronuclei, and also inhibit their repair! (2/3)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Mitochondria transform micronuclei in time bombs propelling cancer cells towards distant metastasis and therapy resistance!💣⏱️
But....
What is the evolutionary purpose of this mechanism? What makes micronuclei different from the primary nucleus? 🤔
Stay tuned to know more! 🙃
How and why micronuclei rupture?
The answer to this long-lasting conundrum is in my first author paper published, together with its back-to-back companion from @stesantaguida.bsky.social lab, on Science. (1/3)
Happy and honored to be the 2025 recipient of the Physical Cell Biology Early Career Award at the @biophysicalsoc.bsky.social annual meeting! Thanks to the Physical Cell Biology subgroup & PRX Life for awarding my work on micronuclei&mitochondria (to know more about it come Feb 18 room 502B, 11.30!)
