We discovered that micronuclei rupture because of proximity to mitochondria! Mitochondria leak Reactive Oxygen Species that alter nuclear export and protein oligomerization. ROS rupture micronuclei, and also inhibit their repair! (2/3)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Chromosome-containing micronuclei are a hallmark of aggressive cancers. Micronuclei frequently undergo irreversible collapse, exposing their enclosed chromatin to the cytosol. Micronuclear rupture cat...
