Asst Professor, Dept of Biochemistry, Indian Institute of Science
Cell biology, Cytoskeleton, Cell cycle, Synthetic biology, Evolution.
Lab webpage: https://syncellbiolab.weebly.com
Alumnus of UniWarwick|DKFZ|MKU|VIT
Saravanan Palani
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Happy to share that our story on the bacterial archaellum was published today in @natmicrobiol.nature.com
www.nature.com/articles/s41...
Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social
How short can a degron be?
A compact, genetically encoded, 9-aa tunable degron that drives MDM2-dependent degradation enabling precise control of protein levels from yeast to human cells.
Thanks to @eswarappalab.bsky.social for the opportunity to explore this in yeast.
#Degron #Yeast #CellBiology 🧬
Honored and super excited to join the EMBO Global Investigator Programme! Heartfelt thanks to @embo.org for this recognition.
This achievement belongs to my fantastic team at Indian Institute of Science, and to all mentors, colleagues & collaborators whose support truly made it possible. ✨
We’re on the cover of @embojournal.org
Odin, from Norse mythology, emerges from the Odinarchaeota yellowstonii genome, holding FtsZ1 and FtsZ2 the ancestral twins of tubulin highlighting their evolutionary divergence in Asgard archaea. 👉 shorturl.at/n7iZE
#archaea #evolution #tubulin #cytoskeleton
Twelve scientists from Chile, India, Nigeria, Singapore and Taiwan have been selected as new EMBO Global Investigators – Congratulations to the new cohort! 🧪
Read the press release:
https://www.embo.org/press-releases/twelve-scientists-become-embo-global-investigators/
#funding #training
SAVE THE DATE!
The next instalment of the long-running Bacterial and Archaeal Cell Division Conference will take place at www.marriott.com/en-us/hotels..., Italy from the 20th to 23rd of April 2027.
Organisers: me, @s-lab.bsky.social, @awehenkel.bsky.social.
More info soon.
#MicroSky
🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social
We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny.
#ProtistsOnSky #SciComm #SciSky
www.cell.com/cell/fulltex...
Our latest preprint: Together with the team of Jan Löwe, @danieltamarit.bsky.social and many others we discovered and characterized several Asgard tubulin genes and propose that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis
www.biorxiv.org/content/10.6...
One of biggest mysteries in biology: how did complex eukaryotic cells evolve from simple microbes? ~1.8 billion years ago, an archaeal cell likely merged with a bacterium to form the first eukaryotic cell, but can we ever find direct evidence of this transformative event? 🦠 🚶♂️
Bona fide gene clusters for archaella are widespread across a bacterial phylum and encode functional motility machinery.
Glad to share our paper out today @NatureEcoEvo: “Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor”. www.nature.com/articles/s41... #microsky #archaeasky
Video
Saravanan Palani
Saravanan Palani
Saravanan Palani
Would you expect that Bacteria use an archaellum for swimming? We didn't, but we found that some Chloroflexota do! Find the story here: www.biorxiv.org/content/10.1...
A little thread below 1/n
Phylogenetic and biochemical analyses show a diversity of components of the DNA replication machinery in different Asgard archaea that contributed to the eukaryotic DNA replication machinery.
imageimageThe tubulin/FtsZ superfamily of cytoskeletal proteins may have originated in Asgard
archaea. This study reveals different filament morphologies membrane tethering mechanisms
for the dual Fts...
Motility in Archaea is driven by a nanomachinery called the archaellum. So far, archaella have been exclusively described for the archaeal domain; however, a recent study reported the presence of arch...
Twelve scientists from Chile, India, Nigeria, Singapore and Taiwan have been selected as new EMBO Global Investigators – Congratulations to the new cohort! 🧪
Read the press release:
https://www.embo.org/press-releases/twelve-scientists-become-embo-global-investigators/
#funding #training
Sonja-Verena Albers
EMBO
Interested in tunable protein degradation? Check out our new preprint describing a compact, portable degron derived from MTCH2: doi.org/10.64898/202...
Led by Lekha EM
Saubhik Som
Ramon Boro
Sandeep Eswarappa
Great collaboration w/ Anubhav Dhar
Eepsitha
@syncellbiolab.bsky.social
#iiscbangalore
Issue 21 highlights:
Paxilin’s nuclear switch in the brain
RING E3s reading & extending ADPr-ubiquitin
Review: Decoding immunometabolism
Nuclear actin limits chromatin leakage upon migratory squeeze
Cover by @syncellbiolab.bsky.social: unlike Odin-archael FtsZ twins
www.embopress.org/toc/14602075...
