Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation: Molecular Cell www.cell.com/molecular-ce... @raflynn5.bsky.social @vinnieviruses.bsky.social
A new function of glycosylated RNAs has been discovered by Graziano et al. in which
the glycosylation of RNA molecules shields acp³U RNA modification from triggering
innate immune responses.
Thanks to Autoimmunity podcast @kevinbonham.bsky.social & @woodrufflab.bsky.social for discussing our glycoRNA paper w/ @raflynn5.bsky.social @vinnieviruses.bsky.social
Don’t trust the experts”? That’s not democracy, that’s recklessness.
On a plane, I want a pilot.
In a hospital, I want doctors and scientists who understand the evidence.
Expertise isn’t religion or authoritarianism — it’s training, accountability, and data.
Ignore it and we all pay the price.
I'm glad to see this being covered - because, frankly, this is a death-blow to collaborative science - however, the assumption of good faith in any of these decisions by reporters is mind-boggling.
This is happening for one reason - to assure top-down control of what gets funded and what does not.
Thank you for covering our paper!
Vijay Rathinam
In our latest episode, @woodrufflab.bsky.social and @kevinbonham.com talk about glycoRNAs, and the way they're shielded from the immune system in a new paper from the labs of @raflynn5.bsky.social and @vijayrathinam.bsky.social 🧪
audiommunity.org/episodes/epi...
Huge advance in glycoRNA biology. Congrats to @raflynn5.bsky.social and all of the wonderful authors! Can’t wait to see what you guys do next!
In our latest episode, @woodrufflab.bsky.social and @kevinbonham.com talk about glycoRNAs, and the way they're shielded from the immune system in a new paper from the labs of @raflynn5.bsky.social and @vijayrathinam.bsky.social 🧪
audiommunity.org/episodes/epi...
Once in a while, we get the privilege to enjoy works like this:
www.science.org/doi/10.1126/...
Defense-associated reverse transcriptases (DRTs) are widespread bacterial anti-phage systems that use unconventional mechanisms of polynucleotide synthesis. We show that DRT3, which comprises two dist...
The US NIH is stepping back from 'top-down' science.
My latest analysis for @nature.com shows that funding calls have plummeted by 90%, funneling billions into broad, 'investigator-initiated' ideas, rather than targeted, agency-driven ones.
A massive shift for the American biomedical enterprise.
Vincent Graziano
Vincent Graziano
Kristian G. Andersen
US biomedical funding behemoth says the approach will boost innovation, but some researchers worry that understudied areas of science will suffer.
🚨New Paper in Cell 🧵🔎
Happy to share our work led by the @camilahcoelho.bsky.social, on mAbs against mpox.
We were very excited (and lucky!) to contribute to this collab. effort.
🦠“Human monoclonal antibodies targeting A35 protect from death caused by mpox”🦠
doi.org/10.1016/j.cell.2025.08.004
Out today in Nature - our collaborative work with Ryan Flynn's lab, led by Dr. Peiyuan Chai with support from Dr. @sinakheiri.bsky.social and @shahjess.bsky.social from our group. Exciting findings showcasing how glycoRNAs can modulate angiogenesis!
RFK Jr: We need to stop trusting the experts... Trusting the experts is not a feature of science or democracy, it's a feature of religion and totalitarianism.
Max Kozlov
Kurianlab
Video
Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
