#NatMetabPicks | In @cp-cell.bsky.social led by @lydiafinley.bsky.social ( @mskcancercenter.bsky.social ) 🧪
Citrate clearance is an essential function of the TCA cycle via the activity of aconitase 2.
www.cell.com/cell/fulltex...
We are thrilled to announce the 2026 Zara Weinberg Leading Edge Fellows! 40 remarkable postdocs pursuing transformative research in biological/biomedical sciences.
This is the 7th Leading Edge cohort and we are so excited to welcome them!
www.leadingedgesymposium.org/fellows/
The main function of the TCA cycle is to feed electrons into the respiratory chain.
..wait, what!? It also clears excess citrate, because otherwise you get severe kidney damage?
Great example that textbooks aren’t always the full story by Abby, @juliabrunner.bsky.social and @lydiafinley.bsky.social
Julia’s paper identifying Aspartate as a determinant cell-state specific engagement of the Malate-Aspartate-Shuttle is now out @cp-molcell.bsky.social!
Now online! Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle
Thank you so much for highlighting our work- Truly spot on and a great title!
Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the
canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation
and citrate production increa...
@cp-cell.bsky.social is on 🔥 with #immunemetabolism! Zheng &co show that excessive glycolysis-driven pyrivate cause pyruvylation of STAT1 preventing #interferon signaling 👉 doi.org/10.1016/j.ce... & Finley &co show that ACO2 clears citrate preventing integrated stress response & kidney degeneration👇
Very happy to share our new paper. Together with our wonderful collaborators, we found that L-2-HG, a metabolite often viewed as “toxic,” also has an essential physiological function in mice. www.nature.com/articles/s41...
Key roles for monocyte-derived cells in CNS metabolism and reveals the pleiotropic beneficial effects of arginine in neuroinflammation @natimmunol.nature.com @schabbauerlab.bsky.social @meduniwien.ac.at
www.nature.com/articles/s41...
Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increase, aconitase 2 becomes essential to prevent mitochondrial citrate accumulation, which can trigger the integrated stress response and impair cell fitness.
dlvr.it
Alex Lercher
Leading Edge Fellows Program
Alex Lercher
Julia S. Brunner
www.cell.com
Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the
canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation
and citrate production increa...
l-2-Hydroxyglutarate is identified as a legitimate physiological signalling metabolite, and control of its levels is essential for postnatal growth and survival and correct renal development and funct...
One more thing- here, together with amazing human being, friend & stellar physician scientist Abby Xie, we identify a new function of the TCA cycle, which is citrate clearance, now online at @cellpress.bsky.social: www.cell.com/cell/fulltex...
Ivan Zanoni
Waggoner Lab
A big chunk of my postdoctoral work on cell-state dependent metabolism is now out at @cp-molcell.bsky.social: www.cell.com/molecular-ce... 1/
Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the
canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation
and citrate production increa...
Check out our Spotlight in Molecular Cell on @lydiafinley.bsky.social's lab recent work on Aconitase 2 and its protective role against impaired cell fitness and ISR activation due to mitochondrial citrate accumulation authors.elsevier.com/c/1n3Nn3vVUP...
Brunner et al. report that malate-aspartate shuttle engagement is cell-state dependent
and can be modulated by the availability of the amino acid aspartate. In differentiated
cells, malate-aspartate s...
