Translational Redox Biology @TU Dresden @redoxlab.bsky.social
Applied chemical biology for research and treatment of cancer and inflammation | science and teaching | she/her | 🌈🇪🇺🇦🇺🏳️🌈🏳️⚧️
scientist/woman/mother/overthinker in academia
Julia Thorn-Seshold
Loading...
Transient vascular disruption as delivery route may be useful for single-shot translational approaches, and for research applications.
Thanks #BMFTR #GO-Bio & #VDI/VDE-IT for supporting the scientific process. From vascular TME modulation @lmu.de to biochemical TME dynamics @tudresden.bsky.social.
Reminder for our GBM Lunch Seminar tomorrow, April 22 at 12:30!
GBM Lunch on May 6, 2026, 12:30
Speaker: Youjun Yang (East China University of Science and Technology)
Title: "Early Ferroptosis Detection Targeting Lipid Hydrogen Abstraction”
Chair: @oliverthornseshold.bsky.social
Organizer: Joint Study Group "Chemical Biology"
#GBMLunch #ChemicalBiology
We tested a way to selectively increase delivery of nano-formulated drugs into solid tumours by disrupting their immature blood vessel system.
In a syngeneic mouse model for TNBC (4T1) we combined
💊 clinically approved nano-formulated drug
💉 low-dose small molecule microtubule destabiliser (CA4P)
In principle:
✅ 2-3 fold increase in drug content inside solid tumours ✅ healthy organs not affected
The catch:
❌ no consistent translation into improved therapeutic efficacy
What happened?
🎯 We made sure that all tumours were large enough to be neo-vascularised at the start of treatment
⏩ fast forward to 2nd/3rd treatment: no CA4P-dependent drug accumulation inside tumours anymore.
Proof of principle vs. translational reality check: Can we accumulate nano-formulated drugs inside solid tumours by transiently disrupting tumour vasculature? Yes, in principle, but with a translational catch 👇
#GO-Bio #BMFTR @lmu.de; #ChemBio bpspubs.onlinelibrary.wiley.com/doi/10.1111/...
Spatio-temporal dynamics of tumour vasculature are hard to predict, even in established models: rapid growth, collapse/reperfusion, normalisation...
➡️ vessel structure likely matured during tumour growth 📈 or even reactively remodeled after therapeutic intervention 💉
❌ effectively losing our target
Out in BJP @britpharmsoc.bsky.social!
Thank you and congrats to all co-authors and collaborators, especially to the three female lead authors! And shoutout to #reviewer2 for the constructive dialogue. This was peer-review as it should be!
Dear Lipid and Membrane Enthusiasts,
There is only one month!! left to register and submit your abstracts for the @embo.org Workshop “Lipid Code to Life”, which will be held from September 7–11, 2026, in Dresden, Germany.
Workshop program and registration page: meetings.embo.org/event/26-lip...
Background and purpose Nano-formulated chemotherapeutics prolong systemic availability of drugs and can reduce systemic toxicity, but their accumulation in solid tumours is often limited and unpredi...
Julia Thorn-Seshold
Julia Thorn-Seshold
Julia Thorn-Seshold
GBM (Gesellschaft für Biochemie und Molekularbiologie)
GBM (Gesellschaft für Biochemie und Molekularbiologie)
