Advanced imaging of ovarian tumor samples shows that PARP inhibitors can become trapped in lysosomes, creating internal drug reservoirs that may influence treatment resistance and effectiveness. doi.org/hbswwr
Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social
One of oncology's biggest challenges is that the same treatment can work well for some patients but fail completely in others.
📣 We’re hiring 6 new Team Science postdocs!
Our Team Science approach brings together interdisciplinary researchers to tackle questions no single field can solve alone.
Find out more and download our brochure below
Congratulations Will Scott and team @mrc-lms.bsky.social on some fantastic work looking at how adipose tissue remodels in obesity and weight loss.
Why do some #cancer cells develop treatment #resistance? The answer may lie in hidden “storage hubs” inside #tumour cells, which create uneven drug exposure across tumours, according to new #research led by @louisefets.bsky.social from 🇬🇧 @mrc-lms.bsky.social.
Excellent opportunity @mrc-lms.bsky.social for a human physiologist to start their own group. Deadline 4th May.
Core funding, excellent package.
Please repost!
lms.mrc.ac.uk/work/vacanci...
lms.mrc.ac.uk
One of oncology’s biggest challenges is that the same treatment can work well for some patients but fail completely in others.
Congrats to the drug transport and tumour metabolism group, headed by @louisefets.bsky.social for winning two awards!
Healthcare in Europe
MRC Laboratory of Medical Sciences
Great collaboration that took us to places we definitely were not anticipating! Thank you Zoe and congratulations to you too! 🎉 ♥️
Join us in Belfast for two days of rigorous metabolic science, ECR-led talks and posters, and exciting opportunities for collaboration. The UK Cancer Metabolism Network is a young but fun and open community - do check out the meeting, registration open until 24th March!
Seconded! Worth a look for anyone who wants to open a lab working on metabolic physiology and/or disease, or immunometabolism
Louise Fets
Louise Fets
Louise Fets
Louise Fets
A new study, published today in Nature, reveals the hidden benefits of weight loss on fat tissue.
A better understanding of how weight loss leads to health improvements at a molecular level could help inform the development of therapies for diseases such as type 2 diabetes in the future.
In our new paper with @louisefets.bsky.social we show with #MSI that drugs can accumulate heterogeneously in #ovarian #cancer and may explain why treatments work well in some patients and not others. Huge congrats to Carmen Ramirez Moncayo, Louise and all authors! bit.ly/4byaY9W
Scientists from the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have produced the first detailed characterisation of the changes that weight loss causes in human fat tissue by...
We're recruiting junior team leaders @mrc-lms.bsky.social This time we're looking for those working in human metabolic disease.
It's a great place to start your lab. Fantastic colleagues, exciting science, world class facilities. Join us!
lms.mrc.ac.uk/work/vacanci...
Alexis Barr
We are recruiting Programme Leader Track positions focusing on 1) Metabolic Physiology using murine and/or human in vivo models and 2) Immunometabolism.
