Stuck between a ROCK2 and a hard place?
New research just out shows selective ROCK2 inhibition reduces microvascular obstruction after myocardial I/R but doesn’t limit infarct size. Highlights distinct roles for ROCK isoforms in #cardioprotection. 🫀
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#CardioSky
Myocardial ischaemia/reperfusion (I/R) injury causes infarction, microvascular obstruction (MVO), and haemorrhage. MVO, often driven by vasospasm, lac…
🫀🦠 How does #COVID19 damage the heart?
New research from Gross et al. using human iPSC-derived #cardiomyocytes uncovers cellular responses to SARS-CoV-2, shedding light on mechanisms of cardiac injury.
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🧪 Just out: a new #review of Rac1-driven signalling in cardiomyocytes — covering #hypertrophy, #arrhythmia and #redox stress.
A must-read for anyone in cardiac research! 💙
#Cardiology #HeartResearch #SignalTransduction #CardioSky
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On your way to #AHA or just looking for some weekend reading?
Check out the latest paper from Warren et al who uncovered region-specific metabolic and signalling changes in the endocardium vs epicardium in a mini-pig model of #HCM 🫀🫀
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#CardioSky #AnimalModel
🫀New research demonstrates that high-throughput, label-free optical oxygen measurements can assess adrenergic effects in iPSC-derived #cardiomyocytes
Paired with all-optical #electrophysiology, this enables scalable, human-based preclinical testing
#CardioSky
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The disease-causing myosin variant (MYH7-403Q) is linked to hypertrophic cardiomyopathy (HCM). We carried out a research study of signaling pathways i…
Rate- and contractility-modulating drugs, such as adrenergic agonists and antagonists, are widely used in the treatment of cardiovascular conditions. …
Cardiovascular disease remains the leading cause of mortality globally and is often marked by pathologic cardiac remodeling including hypertrophy and …
Rab10 to the rescue! 🦸♂️🫀!
New study from Xu et al. in the December issue shows how this tiny protein helps keep harmful heart growth in check.
Read more at:
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#CardioProtection #Hypertrophy #CardioSky
🚨 New paper alert! Feder et al. have recently shown that persistently increased #CaMKIIδ autophosphorylation drives pathological sarcoplasmic reticulum #calcium loss in a murine model of #doxorubicin-induced #cardiomyopathy. 💔
➡️📉 Check it out:
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New work from Daoud et al. shows that removal of YAP/TAZ from vascular smooth muscle cells triggers inflammation and immune activation- indicating these factors as essential in vascular health.#vascularbiology
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#CardioSky
💓 New research from Achlaug et al. @technion.bsky.social reveals how cancer-driven cytokine signalling improves cardiac function and reduces fibrosis.
Tumour–heart crosstalk with major therapeutic implications
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#CardioOncology #Immunology #Fibrosis #Research
Doxorubicin (DOX)-induced cardiomyopathy (DICM) manifests as left ventricular (LV) systolic dysfunction. DOX triggers oxidative stress and CaMKIIδ act…
We often treat #diabetes and #heart #disease separately — but they’re connected🫀.
A recent study from Srinivas, Alluri et al. shows that removing CHOP in β-cells protects against both metabolic dysfunction and cardiac fibrosis in T2D mice.
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#CardioSky #NewPaper
Prolonged cardiac hypertrophy is a main risk factor for heart failure (HF). During cardiac hypertrophy remodelling, there is an increase in protein sy…
The transcriptional co-activators YAP (YAP1) and TAZ (WWTR1) are central regulators of vascular smooth muscle cell (VSMC) phenotype and vascular homeo…
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Heart failure remains a leading cause of morbidity and mortality worldwide, with limited progress in the development of novel therapies. It has been d…
Cardiovascular complications are the leading cause of morbidity and mortality in patients with type 2 diabetes (T2D), which is recognized as a major i…
