New work from Daoud et al. shows that removal of YAP/TAZ from vascular smooth muscle cells triggers inflammation and immune activation- indicating these factors as essential in vascular health.#vascularbiology
sciencedirect.com/science/arti...
#CardioSky
🫀🦠 How does #COVID19 damage the heart?
New research from Gross et al. using human iPSC-derived #cardiomyocytes uncovers cellular responses to SARS-CoV-2, shedding light on mechanisms of cardiac injury.
www.sciencedirect.com/science/arti...
🫀New research demonstrates that high-throughput, label-free optical oxygen measurements can assess adrenergic effects in iPSC-derived #cardiomyocytes
Paired with all-optical #electrophysiology, this enables scalable, human-based preclinical testing
#CardioSky
www.sciencedirect.com/science/arti...
The transcriptional co-activators YAP (YAP1) and TAZ (WWTR1) are central regulators of vascular smooth muscle cell (VSMC) phenotype and vascular homeo…
sciencedirect.com
Rate- and contractility-modulating drugs, such as adrenergic agonists and antagonists, are widely used in the treatment of cardiovascular conditions. …
We often treat #diabetes and #heart #disease separately — but they’re connected🫀.
A recent study from Srinivas, Alluri et al. shows that removing CHOP in β-cells protects against both metabolic dysfunction and cardiac fibrosis in T2D mice.
sciencedirect.com/science/arti...
#CardioSky #NewPaper
Rab10 to the rescue! 🦸♂️🫀!
New study from Xu et al. in the December issue shows how this tiny protein helps keep harmful heart growth in check.
Read more at:
www.sciencedirect.com/science/arti...
#CardioProtection #Hypertrophy #CardioSky
🚨 New paper alert! Feder et al. have recently shown that persistently increased #CaMKIIδ autophosphorylation drives pathological sarcoplasmic reticulum #calcium loss in a murine model of #doxorubicin-induced #cardiomyopathy. 💔
➡️📉 Check it out:
www.sciencedirect.com/science/arti...
Stuck between a ROCK2 and a hard place?
New research just out shows selective ROCK2 inhibition reduces microvascular obstruction after myocardial I/R but doesn’t limit infarct size. Highlights distinct roles for ROCK isoforms in #cardioprotection. 🫀
www.sciencedirect.com/science/arti...
#CardioSky
💓 New research from Achlaug et al. @technion.bsky.social reveals how cancer-driven cytokine signalling improves cardiac function and reduces fibrosis.
Tumour–heart crosstalk with major therapeutic implications
www.sciencedirect.com/science/arti...
#CardioOncology #Immunology #Fibrosis #Research
On your way to #AHA or just looking for some weekend reading?
Check out the latest paper from Warren et al who uncovered region-specific metabolic and signalling changes in the endocardium vs epicardium in a mini-pig model of #HCM 🫀🫀
sciencedirect.com/science/arti...
#CardioSky #AnimalModel
Cardiovascular complications are the leading cause of morbidity and mortality in patients with type 2 diabetes (T2D), which is recognized as a major i…
sciencedirect.com
🧪 Just out: a new #review of Rac1-driven signalling in cardiomyocytes — covering #hypertrophy, #arrhythmia and #redox stress.
A must-read for anyone in cardiac research! 💙
#Cardiology #HeartResearch #SignalTransduction #CardioSky
www.sciencedirect.com/science/arti...
Prolonged cardiac hypertrophy is a main risk factor for heart failure (HF). During cardiac hypertrophy remodelling, there is an increase in protein sy…
www.sciencedirect.com
Doxorubicin (DOX)-induced cardiomyopathy (DICM) manifests as left ventricular (LV) systolic dysfunction. DOX triggers oxidative stress and CaMKIIδ act…
Heart failure remains a leading cause of morbidity and mortality worldwide, with limited progress in the development of novel therapies. It has been d…
www.sciencedirect.com
JMCC Plus
JMCC Plus
The disease-causing myosin variant (MYH7-403Q) is linked to hypertrophic cardiomyopathy (HCM). We carried out a research study of signaling pathways i…
Cardiovascular disease remains the leading cause of mortality globally and is often marked by pathologic cardiac remodeling including hypertrophy and …
