This study led by @flavia-con.bsky.social from the Brockdorff lab is finally published at Nature Communications!
www.nature.com/articles/s41...
Using live-cell and single-molecule imaging, this work dissects how the epigenetic regulator #SMCHD1 interacts with chromatin during X-inactivation.
Stunning work — acquisition of IDRs in SON appears to have driven the evolution of nuclear speckles, enabling selective splicing of GC-rich intron–exon units.
Today we celebrate our colleagues Colin Kleanthous and Rob Klose as they join the Fellowship of the Royal Society, one of the highest honours in the scientific world, in recognition of their impactful contributions to knowledge. Congratulations! 👏 👏 👏
Read more ⬇️
🧵 Happy to share that the final version of our study is finally out in @natcomms.nature.com today:
www.nature.com/articles/s41...
What started as an unexpected observation—that SETDB1 depletion accelerates X chromosome silencing—led us to uncover a role for SETDB1 in regulating Xist transcription.
New paper! How do RNAs "know" where to go inside a cell? We dug into the sequence elements that route RNAs to the right place. It turns out that, in mammals, they're surprisingly massive (>200 nt), multipartite, and wonderfully complicated. 🧵
Very importantly, one of the co-organisers @xrnchew.bsky.social is cycling to the meeting to raise awareness and funds for 'All things small and green' . Please join him or sponsor him!
gofund.me/f4068dc3c
Two new papers 📖 from our lab 1️⃣ What is epigenetics (and why X inactivation is?) rdcu.be/fhzSz and 2️⃣ A Baculovirus-based tool to express any gene of interest with high efficiency in Anopheles cells rdcu.be/fhzTy
Postdoc position available now in the Smith Group lsi.exeter.ac.uk/groups/smith... to test the hypothesis that differentiation biases between human pluripotent stem cell lines may be eliminated by reversion to the naïve state.
careers.exeter.ac.uk/vacancies/79...