This study led by @flavia-con.bsky.social from the Brockdorff lab is finally published at Nature Communications!
www.nature.com/articles/s41...
Using live-cell and single-molecule imaging, this work dissects how the epigenetic regulator #SMCHD1 interacts with chromatin during X-inactivation.
SMCHD1 is a key player in X chromosome inactivation in mammals and has been linked to two human disorders. Here, the authors present insight into SMCHD1’s mode of interaction and functionality at its ...
Fresh preprint by @flavia-con.bsky.social from our lab uncovers how SMCHD1 finds & binds chromatin using live-cell single-molecule imaging🔬
She reveals how SMCHD1 dynamically engages chromatin, including the inactive X chromosome, to maintain gene silencing.
www.biorxiv.org/content/10.1...
Guifeng Wei
The chromosomal protein SMCHD1 is a GHKL ATPase that plays important roles in epigenetic silencing, including on the inactive X chromosome (Xi) and at the D4Z4 macrosatellite linked to regulation of D...
