Cooperatively-bound tau inhibits kinesin-1 (KIF5B) motility, and inhibition is relieved by phosphorylation. In contrast, kinesin-3 (KIF1A) is strongly inhibited by both phosphoresistive and phosphomimetic tau.
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Huntingtin polyglutamine expansions misdirect axonal transport by perturbing motor and adaptor recruitment: iScience www.cell.com/iscience/ful...
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doi.org/10.7554/eLif...
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Tau phosphorylation also relieves inhibition of lysosome transport by tau in neurons and alters the distribution of lysosomes in axons.
Similarly, phosphorylation blocks the ability of tau to bind cooperatively in neurons