Our recent work showing that tau phosphorylation alters cooperative binding and organelle transport in neurons is now posted at @elife.bsky.social. A big thanks to the reviewers and editors for their thoughtful assessment.
doi.org/10.7554/eLif...
Adam Hendricks
doi.org
A few highlights from our new preprint:
On taxol-stabilized microtubules In vitro, wild-type (WT) and phosphor-resistive (AP) tau form well-defined envelopes, while phosphomimetic (E14) tau does not bind cooperatively.
Adam Hendricks
Very happy to share our latest work on tau. We show that tau binds cooperatively in living neurons. Phosphorylation disrupts tau envelopes, and misregulates axonal transport.
www.biorxiv.org/content/10.1...
Tau, a neuronal microtubule-associated protein (MAP), organizes the axonal cytoskeleton and regulates intracellular transport. Tau hyperphosphorylation is closely linked to neurodegeneration in tauopa...
