New work by the van Oudenaarden group shows how gene expression and chromatin state become progressively more aligned as differentiation proceeds over the first day of zebrafish embryo development. Learn more in the thread below by first author @vivekbhr.bsky.social.
Today, Mara Bouwman successfully defended her PhD thesis on heart regeneration. She discovered that two genes are required for heart regeneration in zebrafish and investigated one of them in mammals, finding promising results. Congratulations Mara! 🎉 Read more: www.hubrecht.eu/phd-bouwman/
Chronic lung disease and inflammation often go hand-in-hand, but how does inflammation impact lung repair? Antonella Dost, former Postdoc in the Clevers group, developed a human organoid model that mimics lung air sacs. Surprisingly, specific immune signals both help and hinder lung regeneration.
Today, Eirini Kyriakopoulou successfully defended her PhD thesis! 🎓 She explored whether gene therapy can tackle the genetic heart disease ACM. Her work has led to clinical trials, currently testing gene therapy in patients. Congratulations Eirini! Read more here 👉 www.hubrecht.eu/phd-kyriakopoulou
Using live microscopy in zebrafish, researchers from the Robin group discovered a new type of macrophage that permanently resides within blood vessels. This discovery explains how the immune system protects the vascular system. Read more: www.hubrecht.eu/patrol-offic...
For 110 years, the Hubrecht Institute has been studying the development of cells, tissues and organisms to discover how life works on the smallest scale. To celebrate this, we are opening our doors on Saturday, 6 June 2026. Read more here: www.hubrecht.eu/zooming-in-o...
Danny Sahtoe has been awarded the NVBMB prize. The jury was impressed with Sahtoe's consistently strong work on protein structure, function and design during his PhD and postdoc. The prize includes funding to organize a symposium on a topic of choice. Read more: www.hubrecht.eu/nvbmb-price-...
Group leader Miguel Leung has been awarded the Young Scientists Award 2026 from @heinekenprizes.bsky.social . With his group, he investigates the 3D structure of protein complexes, tiny machines at work inside each of our cells. Congratulations, Miguel! Read more: www.hubrecht.eu/heineken-you...
Congratulations! Jeroen den Hertog, @bakkerslab.bsky.social , @fmattiroli.bsky.social and Eva van Rooij received ZonMw Open competition grants to study RASopathies and heart regeneration. Read more here: www.hubrecht.eu/zonmw-grants...
Oocytes store large amounts of proteins to support the earliest developmental stages. In @nature.com, the Leung group describes the structure of the cytoplasmic lattice in unprecedented detail. At least 13 different proteins assemble into a stable storage complex. hubrecht.eu/oocyte-storage-complex/
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Video
Interferon‑γ selectively promotes survival of alveolar progenitor cells in a human lung organoid model
– @antonelladost.bsky.social et al @thecleverslab.bsky.social describe a reductionist platform for discovering strategies to enhance alveolar regeneration
link.springer.com/article/10.1...
Our research work on using #singlecell co-mapping to study early embryonic development is now published: doi.org/10.7554/eLif....
The EMBO Journal
Vivek Bhardwaj
Disease of the lung alveoli is frequently associated with acute or chronic inflammation. At present, there are no effective therapies to support regeneration of the alveolar epithelium, and ongoing in...
